抗体

PTPN11

030580

100微升

502美元

单克隆

小鼠

未共轭

13B658

PTPN11

小鼠

单克隆抗体

抗体

100微升

502美元

13B658

IgG1

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. Two transcript variants encoding different isoforms have been found for this gene. Applications: Western Blot: 1:500-1:2000 Immunohistochemistry: 1:200-1:1000 Immunocytochemistry: 1:200-1:1000 Flow Cytometry: 1:200-1:400 ELISA: 1:10000 Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Hu

CFC;NS1;SHP2;BPTP3;PTP2C;PTP-1D;SH-PTP2;SH-PTP3;MGC14433

纯化重组片段对应于人PTPN11(AA: 263-329)在大肠杆菌中表达

人类

纯化

Purified antibody in PBS with 0.05% sodium azide and 0.5% protein stabilizer

~1毫克/毫升

Product Type: Mab Isotype: IgG1 Clone No: 13B658 Host: mouse Source: human Concentration: ~1mg/ml Form: Purified antibody in PBS with 0.05% sodium azide and 0.5% protein stabilizer Purity: Purified Immunogen: Purified recombinant fragment of human PTPN11 (AA: 263-329) expressed in E. coli. Specificity: Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

E FC细胞化学免疫组化免疫印迹

-20°C

1.Blood. 2011 Aug 11;118(6):1504-15. 2.Cancer Cell. 2011 May 17;19(5):629-39.