STAT3 (Signal transducer and activator of transcription 3, Acute-phase response factor)

产品简要

公司名称 :

US Biological

产品类型 :

抗体

产品名称 :

STAT3 (Signal transducer and activator of transcription 3, Acute-phase response factor)

030663

规格 :

100微升

价格 :

473美元

克隆性 :

单克隆

宿主 :

小鼠

共轭标签 :

未共轭

克隆名称 :

13B741

反应物种 :

人类

更多信息或购买 :

US Biological 产品网页

产品信息

目录号 :

030663

Product wo Prefix :

STAT3 (Signal transducer and activator of transcription 3, Acute-phase response factor)

宿主 :

小鼠

产品类型 :

单克隆抗体

类别 :

抗体

尺寸1 :

100微升

Size1 List :

473美元

克隆#USB :

13B741

抗体亚型 :

IgG1

Desc1 :

The Stat3 transcription factor is an important signaling molecule for many cytokines and growth-factor receptors and is required for murine fetal development . Stat3 is constitutively activated in a number of human tumors and possesses oncogenic potential and anti-apoptotic activities. Stat3 is activated by phosphorylation at Tyr705, which induces dimerization, nuclear translocation and DNA binding. Transcriptional activation seems to be regulated by phosphorylation at Ser727 through the MAPK or mTOR pathways. Stat3 isoform expression appears to reflect biological function as the relative expression levels of Stat3α (86kD) and Stat3β (79kD) depend on cell type, ligand exposure or cell maturation stage. It is notable that Stat3β lacks the serine phosphorylation site within the carboxy-terminal transcriptional activation domain.Tissue specificity: Heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Applications: Western Bloting: 1:500-1:2000. Immunohistochemistry: 1:200-1:1000. Immunofluorescence: 1:200-1:1000. ELISA: Suggested dilution 1:10000. Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Calc Crossreactivity :

Hu Mk Mo

又名 :

APRF;HIES;FLJ20882;MGC16063;STAT3

免疫原 :

纯化重组片段对应于人STAT3在大肠杆菌中表达

特异性 :

Human, Mouse, Monkey

纯度 :

腹水

形式 :

Ascites fluid, 0.03% sodium azide.

浓度 :

未确定

Desc2 :

Product Type: Mab Isotype: IgG1 Clone No: 13B741 Host: mouse Source: human Concentration: Not determined Form: Ascites fluid, 0.03% sodium azide. Purity: Ascites Immunogen: Purified recombinant fragment of human STAT3 expressed in E. coli. Specificity: Human, Mouse, Monkey Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Calc Applications Abbrev :

E免疫组化免疫印迹

储存温度 :

-20°C

参考文献 :

1. J Mol Graph Model. 2009 Nov;28(4):347-56. 2. Bone. 2010 Feb;46(2):524-33.

更多信息或购买 :

US Biological 产品网页

公司信息