抗体

GSTM1 (GSTM1, GST1, Glutathione S-transferase Mu 1, GST HB subunit 4, GST class-mu 1, GSTM1-1, GSTM1a-1a, GSTM1b-1b, GTH4)

031008

100微升

569美元

单克隆

小鼠

未共轭

524CT17.2。 5

GSTM1 (GSTM1, GST1, Glutathione S-transferase Mu 1, GST HB subunit 4, GST class-mu 1, GSTM1-1, GSTM1a-1a, GSTM1b-1b, GTH4)

小鼠

单克隆抗体

抗体

100微升

569美元

524CT17.2。 5

IgM

Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Null mutations of this class mu gene have been linked with an increase in a number of cancers, likely due to an increased susceptibility to environmental toxins and carcinogens. Multiple protein isoforms are encoded by transcript variants of this gene. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1:500-2000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Hu

GSTM1, GST1, Glutathione S-transferase Mu 1, GST HB subunit 4, GST class-mu 1, GSTM1-1, GSTM1a-1a, GSTM1b-1b, GTH4

Synthetic peptide corresponding to between 184-211aa from human GSTM1 conjugated to KLH (NP_000552). Cellular Localization: Cytoplasm. Tissue Location: Liver (at protein level)

识别人类GSTM1

腹水

Supplied as a liquid, crude ascites with 0.09% sodium azide.

As reported

Product Type: Mab Isotype: IgM Clone No: 524CT17.2.5 Host: mouse Source: human Concentration: As reported Form: Supplied as a liquid, crude ascites with 0.09% sodium azide. Purity: Ascites Immunogen: Synthetic peptide corresponding to between 184-211aa from human GSTM1 conjugated to KLH (NP_000552). Cellular Localization: Cytoplasm. Tissue Location: Liver (at protein level) Specificity: Recognizes human GSTM1. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

免疫印迹

-20°C

Palli, D., et al. Mutagenesis 25(6):569-575(2010) Henderson, A.J., et al. Thorax 65(10):897-902(2010) Filonzi, L., et al. Birth Defects Res. Part A Clin. Mol. Teratol. 88(9):743-747(2010) Smith, G., et al. Pharmacogenet. Genomics (2010) In press Wang, T., et al. J. Int. Med. Res. 38(3):977-986(2010)

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