抗体

HGF (HGF, HPTA, Hepatocyte growth factor, Hepatopoietin-A, Scatter factor, Hepatocyte growth factor alpha chain, Hepatocyte growth factor beta chain) (AP)

031014-AP

200微升

711美元

单克隆

小鼠

AP

489CT6.12.6

HGF (HGF, HPTA, Hepatocyte growth factor, Hepatopoietin-A, Scatter factor, Hepatocyte growth factor alpha chain, Hepatocyte growth factor beta chain) (AP)

小鼠

单克隆抗体

AP

抗体

200微升

711美元

489CT6.12.6

IgG1

Hepatocyte growth factor regulates cell growth, cell motility, and morphogenesis by activating a tyrosine kinase signaling cascade after binding to the proto-oncogenic c-Met receptor. Hepatocyte growth factor is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. Its ability to stimulate mitogenesis, cell motility, and matrix invasion gives it a central role in angiogenesis, tumorogenesis, and tissue regeneration. It is secreted as a single inactive polypeptide and is cleaved by serine proteases into a 69-kDa alpha-chain and 34-kDa beta-chain. A disulfide bond between the alpha and beta chains produces the active, heterodimeric molecule. The protein belongs to the plasminogen subfamily of S1 peptidases but has no detectable protease activity. Alternative splicing of this gene produces multiple transcript variants encoding different isoforms. [provided by RefSeq]. Applications: Suitable for use in Western Blot, ELISA. Recommended Dilution: ELISA: 1:1,000 Western Blot: 1:100~250 Storage and Stability: May be stored at 4°C for short-term only. For long-term storage, store at -20°C with the addition of glycerol. Aliquots are stable for at least 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. Do not freeze alkaline phosphatase conjugates which could result in a substantial loss of enzymatic activity. Light sensitive. Note: Applications are based on unconjugated antibody.

Hu

HGF, HPTA, Hepatocyte growth factor, Hepatopoietin-A, Scatter factor, Hepatocyte growth factor alpha chain, Hepatocyte growth factor beta chain

Purified His-tagged HGF protein (fragment).

人类

Purified by Protein G affinity chromatography.

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phophatase (AP).

As reported

Product Type: Mab Isotype: IgG1 Clone No: 489CT6.12.6 Host: mouse Source: human Concentration: As reported Form: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phophatase (AP). Purity: Purified by Protein G affinity chromatography. Immunogen: Purified His-tagged HGF protein (fragment). Specificity: Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

E免疫印迹

4°C不冻结

Shi, E., et al. Anesthesiology 113(5):1109-1117(2010) Hoot, K.E., et al. J. Clin. Invest. 120(10):3606-3616(2010) Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010) Togawa, A., et al. Biochem. Biophys. Res. Commun. 400(2):271-277(2010) Li, F., et al. J. Biol. Chem. 285(36):27673-27685(2010)

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