抗体

SOCS3 (SOCS3, CIS3, SSI3, Suppressor of cytokine signaling 3, Cytokine-inducible SH2 protein 3, STAT-induced STAT inhibitor 3)

031254

100微升

569美元

单克隆

小鼠

未共轭

532CT13.5。 3

SOCS3 (SOCS3, CIS3, SSI3, Suppressor of cytokine signaling 3, Cytokine-inducible SH2 protein 3, STAT-induced STAT inhibitor 3)

小鼠

单克隆抗体

抗体

100微升

569美元

532CT13.5。 3

IgM

SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including gp130, LIF, erythropoietin, insulin, IL12, GCSF and leptin receptors. Binding to JAK2 inhibits its kinase activity. Suppresses fetal liver erythropoiesis. Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells. Regulates IL-6 signaling in vivo (By similarity). Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize IL6ST (By similarity). Applications: Suitable for use in Western Blot, ELISA. Recommended Dilution: ELISA: 1:1,000 Western Blot: 1:500~1600 Storage and Stability: May be stored at 4°C for short-term only. For long-term storage, store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Hu

SOCS3, CIS3, SSI3, Suppressor of cytokine signaling 3, Cytokine-inducible SH2 protein 3, STAT-induced STAT inhibitor 3

SOCS3 Antibody is generated from mouse immunized with recombinant protein of human SOCS3.

人类

腹水

Supplied as a liquid, crude ascites with 0.09% sodium azide.

As reported

Product Type: Mab Isotype: IgM Clone No: 532CT13.5.3 Host: mouse Source: human Concentration: As reported Form: Supplied as a liquid, crude ascites with 0.09% sodium azide. Purity: Ascites Immunogen: SOCS3 Antibody is generated from mouse immunized with recombinant protein of human SOCS3. Specificity: Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

E免疫印迹

-20°C

Stevenson, N.J., et al. FEBS Lett. 584(21):4469-4474(2010) Silva, L.K., et al. Eur. J. Hum. Genet. 18(11):1221-1227(2010) Akhtar, L.N., et al. J. Immunol. 185(4):2393-2404(2010) Sun, L.P., et al. Genet. Mol. Res. 9(3):1518-1524(2010) Michaud, F., et al. PLoS ONE 5 (7), E11908 (2010)

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