产品简要
公司名称 :
US Biological
产品类型 :
抗体
产品名称 :
ABL, phosphorylated (Y412) (p150, Proto-oncogene c-Abl, Abelson murine leukemia viral oncogene homolog 1, Tyrosine-protein kinase ABL1, JTK7, ABL, ABL1)
目录 :
031502
规格 :
200微升
价格 :
569美元
克隆性 :
多克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
抗原修饰 :
磷酸化
反应物种 :
人类
更多信息或购买 :
产品信息
目录号 :
031502
Product wo Prefix :
ABL, phosphorylated (Y412) (p150, Proto-oncogene c-Abl, Abelson murine leukemia viral oncogene homolog 1, Tyrosine-protein kinase ABL1, JTK7, ABL, ABL1)
宿主 :
产品类型 :
多克隆抗体
抗原修饰 :
磷酸化
类别 :
抗体
尺寸1 :
200微升
Size1 List :
569美元
抗体亚型 :
IgG
Desc1 :
The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. The t(9;22) translocation results in the head-to-tail fusion of the BCR (MIM:151410) and ABL1 genes present in many cases of chronic myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1. The ABL1 gene is expressed as either a 6- or 7-kb mRNA transcript, with alternatively spliced first exons spliced to the common exons 2-11. Applications: Suitable for use in Dot Blot, ELISA Recommended Dilution: ELISA: 1:1,000 Western Blot: 1:100-500 Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Calc Crossreactivity :
Hu
又名 :
p150, Proto-oncogene c-Abl, Abelson murine leukemia viral oncogene homolog 1, Tyrosine-protein kinase ABL1, JTK7, ABL, ABL1
免疫原 :
Phospho-ABL-Y412 antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y412 of human ABL.
特异性 :
人类
纯度 :
Purified by Protein A affinity chromatography.
形式 :
以溶解在PBS液体方式提供, pH值7.2, 0.09% 叠氮化钠
浓度 :
As reported
Desc2 :
Product Type: Pab Isotype: IgG Host: rabbit Source: human Concentration: As reported Form: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide. Purity: Purified by Protein A affinity chromatography. Immunogen: Phospho-ABL-Y412 antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y412 of human ABL. Specificity: Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Calc Applications Abbrev :
DB E免疫印迹
储存温度 :
-20°C
参考文献 :
Fabbro, D., et al. Biochim. Biophys. Acta 1804(3):454-462(2010) Kim, M.J., et al. Cancer Genet. Cytogenet. 196(2):184-188(2010) Lewandowski, K., et al. Pol. Arch. Med. Wewn. 119(12):789-794(2009) Li, Y.N., et al. Zhonghua Nei Ke Za Zhi 48(6):481-484(2009) Wissing, J., et al. Mol. Cell Proteomics 6(3):537-547(2007) Olsen, J.V., et al. Cell 127(3):635-648(2006)
更多信息或购买 :
公司信息
US Biological
4 Technology Way
Salem, MA01970
tech@usbio.net
https://www.usbio.net
800-520-3011 781-639-5092
公司总部: 美国
United States Biological是生命科学领域的知名品牌,致力于用真实、有价值的个性化采购经验降低研究用成本。