抗体

Akt1, NT (Akt1, Akt, Rac, RAC-alpha serine/threonine-protein kinase, AKT1 kinase, Protein kinase B, Protein kinase B alpha, Proto-oncogene c-Akt, RAC-PK-alpha, Thymoma viral proto-oncogene) (AP)

031752-AP

200微升

711美元

多克隆

domestic rabbit

AP

Akt1, NT (Akt1, Akt, Rac, RAC-alpha serine/threonine-protein kinase, AKT1 kinase, Protein kinase B, Protein kinase B alpha, Proto-oncogene c-Akt, RAC-PK-alpha, Thymoma viral proto-oncogene) (AP)

兔

多克隆抗体

AP

抗体

200微升

711美元

IgG

This gene encodes the founding member of the Akt serine-threonine protein kinase gene family that also includes Akt2 and Akt3. This kinase is a major downstream effector of the phosphatidylinositol 3-kinase (PI3K) pathway that mediates the effects of various growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), insulin and insulin-like growth factor I (IGF-I). It is activated through recruitment to cellular membranes by PI3K lipid products and by phosphorylation by 3-phosphoinositide dependent kinase-1. It then further phosphorylates different downstream proteins in response to various extracellular signals and thus plays a pivotal role in mediating a variety of cellular processes, such as glucose metabolism, glycogen biosynthesis, protein synthesis and turn over, inflammatory response, cell survival (anti-apoptosis) and development. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]. Applications: Suitable for use in Western Blot, Immunohistochemistry and ELISA. Other applications have not been tested. Recommended Dilution: Immunohistochemistry: Formalin-fixed, paraffin-embedded sections Optimal dilutions to be determined by the researcher. Storage and Stability: Store product at 4°C. DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Note: Applications are based on unconjugated antibody.

Mo

Akt1, Akt, Rac, RAC-alpha serine/threonine-protein kinase, AKT1 kinase, Protein kinase B, Protein kinase B alpha, Proto-oncogene c-Akt, RAC-PK-alpha, Thymoma viral proto-oncogene

KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 22-49 in the N-terminal region of mouse Akt1. Species sequence homology: human

识别小鼠Akt1

Purified by Protein A and peptide affinity chromatography.

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phophatase (AP).

As reported

Product Type: Pab Isotype: IgG Host: rabbit Source: mouse Concentration: As reported Form: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phophatase (AP). Purity: Purified by Protein A and peptide affinity chromatography. Immunogen: KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 22-49 in the N-terminal region of mouse Akt1. Species sequence homology: human Specificity: Recognizes mouse Akt1 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

E免疫组化免疫印迹

4°C不冻结

1. Chang, Z., et al. Dev. Biol. 347(2):384-391(2010) 2. Zhou, F., et al. Am. J. Pathol. 177(4):2124-2133(2010) 3. Sun, X., et al. Proc. Natl. Acad. Sci. U.S.A. 107(39):16887-16892(2010) 4. Goncalves, M.D., et al. PLoS ONE 5 (9), E12707 (2010) : 5. Bremer, J., et al. PLoS ONE 5 (8), E12450 (2010) :

https://usbio-images.r.worldssl.net/prodimages/37/031752-AP_1.png