抗体

Androgen receptor, ID (AR, DHTR, NR3C4, Dihydrotestosterone receptor, Nuclear receptor subfamily 3 group C member 4)

031869

200微升

569美元

多克隆

domestic rabbit

未共轭

Androgen receptor, ID (AR, DHTR, NR3C4, Dihydrotestosterone receptor, Nuclear receptor subfamily 3 group C member 4)

兔

多克隆抗体

抗体

200微升

569美元

IgG

The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoforms have been described. [provided by RefSeq]. Applications: Suitable for use in Western Blot. Other applications have not been tested. Recommended Dilution: Western Blot: 1:1000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Hu

AR, DHTR, NR3C4, Dihydrotestosterone receptor, Nuclear receptor subfamily 3 group C member 4

合成多肽对应于474-504来自中央片段人的雄激素受体, ,KLH偶联(P10275)

识别人类雄激素受体

Purified by Protein A affinity chromatography.

以溶解在PBS液体方式提供, pH值7.2, 0.09% 叠氮化钠

As reported

Product Type: Pab Isotype: IgG Host: rabbit Source: human Concentration: As reported Form: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide. Purity: Purified by Protein A affinity chromatography. Immunogen: Synthetic peptide corresponding to 474-504 from the central region of human Androgen receptor, conjugated to KLH (P10275). Specificity: Recognizes human Androgen receptor. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

免疫印迹

-20°C

1. Shu, S.K., et al. J. Biol. Chem. 285(43):33045-33053(2010) 2. Nedelsky, N.B., et al. Neuron 67(6):936-952(2010) 3. Panda, B., et al. Gynecol. Endocrinol. (2010) In press : 4. Schneider, G., et al. Am J Geriatr Psychiatry (2010) In press :5. Guadalupe-Grau, A., et al. PLoS ONE 5 (7), E11529 (2010) :

https://usbio-images.r.worldssl.net/prodimages/33/031869_1.jpg