抗体

APC, ID (APC, DP2.5, Adenomatous polyposis coli protein, Deleted in polyposis 2.5) (AP)

031955-AP

200微升

711美元

多克隆

domestic rabbit

AP

APC, ID (APC, DP2.5, Adenomatous polyposis coli protein, Deleted in polyposis 2.5) (AP)

兔

多克隆抗体

AP

抗体

200微升

711美元

IgG

This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product. Applications: Suitable for use in Western Blot and ELISA. Other applications not tested. Recommended Dilutions: Optimal dilutions to be determined by the researcher. Storage and Stability: Store product at 4°C. DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Note: Applications are based on unconjugated antibody.

Mo

APC, DP2.5, Adenomatous polyposis coli protein, Deleted in polyposis 2.5

KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 1148-1176 in the C-terminal region of human APC.

Recognizes APC. Species Crossreactivity: mouse

Purified by Protein A and peptide affinity chromatography.

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phophatase (AP).

As Reported

Product Type: Pab Isotype: IgG Host: rabbit Concentration: As Reported Form: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phophatase (AP). Purity: Purified by Protein A and peptide affinity chromatography. Immunogen: KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 1148-1176 in the C-terminal region of human APC. Specificity: Recognizes APC. Species Crossreactivity: mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

E免疫印迹

4°C不冻结

1. Chung, K.H., et al. J Neurosurg Pediatr 6(4):372-376(2010). 2. Rai, K., et al. Cell 142(6):930-942(2010). 3. Poulogiannis, G., et al. Proc. Natl. Acad. Sci. U.S.A. 107(34):15145-15150(2010). 4. Jaulin, F., et al. J. Cell Biol. 190(3):443-460(2010). 5. Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)

https://usbio-images.r.worldssl.net/prodimages/13/031955-AP_1.pdf