产品简要
公司名称 :
US Biological
产品类型 :
抗体
产品名称 :
BRCA1, NT (BRCA1, RNF53, Breast cancer type 1 susceptibility protein, RING finger protein 53) (APC)
目录 :
032572-APC
规格 :
200微升
价格 :
711美元
克隆性 :
多克隆
宿主 :
domestic rabbit
共轭标签 :
APC
反应物种 :
人类
更多信息或购买 :
产品信息
目录号 :
032572-APC
Product wo Prefix :
BRCA1, NT (BRCA1, RNF53, Breast cancer type 1 susceptibility protein, RING finger protein 53) (APC)
宿主 :
产品类型 :
多克隆抗体
共轭标签 :
APC
类别 :
抗体
尺寸1 :
200微升
Size1 List :
711美元
抗体亚型 :
IgG
Desc1 :
This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified. [provided by RefSeq]. Applications: Suitable for use in Western Blot and FLISA. Other applications have not been tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: Store product at 4°C in the dark. DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: APC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Note: Applications are based on unconjugated antibody.
Calc Crossreactivity :
Hu
又名 :
BRCA1, RNF53, Breast cancer type 1 susceptibility protein, RING finger protein 53
免疫原 :
KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 443-472 in the N-terminal region of human BRCA1, UniProt Accession #P38398.
特异性 :
识别人类乳腺癌1号基因
纯度 :
Purified by Protein A and peptide affinity chromatography.
形式 :
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC).
浓度 :
As reported
Desc2 :
Product Type: Pab Isotype: IgG Host: rabbit Source: human Concentration: As reported Form: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC). Purity: Purified by Protein A and peptide affinity chromatography. Immunogen: KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 443-472 in the N-terminal region of human BRCA1, UniProt Accession #P38398. Specificity: Recognizes human BRCA1. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Calc Applications Abbrev :
FL免疫印迹
储存温度 :
4°C不冻结
参考文献 :
1. Matsuoka, S., et al. Science 316(5828):1160-1166(2007) 2. Olsen, J.V., et al. Cell 127(3):635-648(2006) 3. Fabbro, M., et al. J. Biol. Chem. 279(30):31251-31258(2004) 4. Ouchi, M., et al. J. Biol. Chem. 279(19):19643-19648(2004) 5. Orban, T.I., et al. MP, Mol. Pathol. 56(4):191-197(2003)
Picture 1 File Name :
https://usbio-images.r.worldssl.net/prodimages/12/032572-APC_1.png
更多信息或购买 :
公司信息
US Biological
4 Technology Way
Salem, MA01970
tech@usbio.net
https://www.usbio.net
800-520-3011 781-639-5092
公司总部: 美国
United States Biological是生命科学领域的知名品牌,致力于用真实、有价值的个性化采购经验降低研究用成本。