产品简要
公司名称 :
US Biological
产品类型 :
抗体
产品名称 :
CD209, ID (CD209, CLEC4L, CD209 antigen, C-type lectin domain family 4 member L, Dendritic cell-specific ICAM-3-grabbing non-integrin 1, CD209) (APC)
目录 :
033478-APC
规格 :
200微升
价格 :
711美元
克隆性 :
多克隆
宿主 :
domestic rabbit
共轭标签 :
APC
反应物种 :
人类
更多信息或购买 :
产品信息
目录号 :
033478-APC
Product wo Prefix :
CD209, ID (CD209, CLEC4L, CD209 antigen, C-type lectin domain family 4 member L, Dendritic cell-specific ICAM-3-grabbing non-integrin 1, CD209) (APC)
宿主 :
产品类型 :
多克隆抗体
共轭标签 :
APC
类别 :
抗体
尺寸1 :
200微升
Size1 List :
711美元
抗体亚型 :
IgG
Desc1 :
CD209 encodes a transmembrane receptor and is often referred to as DC-SIGN because of its expression on the surface of dendritic cells and macrophages. The encoded protein is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses with a large impact on public health. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity. Variations in the number of 23 amino acid repeats in the neck domain of this protein are rare but have a significant impact on ligand binding ability. This gene is closely related in terms of both sequence and function to a neighboring gene (GeneID 10332; often referred to as L-SIGN). DC-SIGN and L-SIGN differ in their ligand-binding properties and distribution. Applications: Suitable for use in Western Blot, FLISA Recommended Dilution: FLISA: 1:1,000 Western Blot: 1:100-500 Storage and Stability: Store product at 4°C in the dark. DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: APC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Note: Applications are based on unconjugated antibody.
Calc Crossreactivity :
Hu
又名 :
CD209, CLEC4L, CD209 antigen, C-type lectin domain family 4 member L, Dendritic cell-specific ICAM-3-grabbing non-integrin 1, CD209
免疫原 :
CD209 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 336~365 amino acids from the Central region of human CD209.
特异性 :
人类
纯度 :
Purified by Protein A affinity chromatography.
形式 :
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC).
浓度 :
As reported
Desc2 :
Product Type: Pab Isotype: IgG Host: rabbit Source: human Concentration: As reported Form: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC). Purity: Purified by Protein A affinity chromatography. Immunogen: CD209 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 336~365 amino acids from the Central region of human CD209. Specificity: Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Calc Applications Abbrev :
FL免疫印迹
储存温度 :
4°C不冻结
参考文献 :
Mosbruger, T.L., et al. J. Infect. Dis. 201(9):1371-1380(2010) Hsu, S.C., et al. J. Biol. Chem. 285(11):7903-7910(2010) Khoo, U.S., et al. J. Mol. Med. 86(8):861-874(2008) Feinberg, H., et al. J. Biol. Chem. 280(2):1327-1335(2005) Appelmelk, B.J., et al. J. Immunol. 170(4):1635-1639(2003) Engering, A., et al. J. Immunol. 168(5):2118-2126(2002)
Picture 1 File Name :
https://usbio-images.r.worldssl.net/prodimages/47/033478-APC_1.jpg
更多信息或购买 :
公司信息
US Biological
4 Technology Way
Salem, MA01970
tech@usbio.net
https://www.usbio.net
800-520-3011 781-639-5092
公司总部: 美国
United States Biological是生命科学领域的知名品牌,致力于用真实、有价值的个性化采购经验降低研究用成本。