抗体

COL1A1, CT(COL1A1, 胶原甲1(I)链, 甲1Ⅰ型胶原)(APC)

034087-APC

200微升

711美元

多克隆

domestic rabbit

APC

COL1A1, CT(COL1A1, 胶原甲1(I)链, 甲1Ⅰ型胶原)(APC)

兔

多克隆抗体

APC

抗体

200微升

711美元

IgG

This gene encodes the pro-alpha1 chains of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIA, Ehlers-Danlos syndrome Classical type, Caffey Disease and idiopathic osteoporosis. Reciprocal translocations between chromosomes 17 and 22, where this gene and the gene for platelet-derived growth factor beta are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans, resulting from unregulated expression of the growth factor. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene. [provided by R. Dalgleish]. Applications: Suitable for use in Western Blot, Immunohistochemistry and FLISA. Other applications have not been tested. Recommended Dilution: Immunohistochemistry: Formalin-fixed, paraffin-embedded sections Optimal dilutions to be determined by the researcher. Storage and Stability: Store product at 4°C in the dark. DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: APC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Note: Applications are based on unconjugated antibody.

Hu Mo

COL1A1, 胶原甲1(I)链, 甲1Ⅰ型胶原

KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 1077-1106 in the C-terminal region of human COL1A1. Species Sequence Homology: rat, bovine, chicken

Recognizes human COL1A1. Species Crossreactivity: mouse

Purified by Protein A and peptide affinity chromatography.

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC).

As Reported

Product Type: Pab Isotype: IgG Host: rabbit Source: human Concentration: As Reported Form: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC). Purity: Purified by Protein A and peptide affinity chromatography. Immunogen: KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 1077-1106 in the C-terminal region of human COL1A1, UniProt Accession #P02452. Species Sequence Homology: rat, bovine and chicken Specificity: Recognizes human COL1A1. Species Crossreactivity: mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

FL免疫组化免疫印迹

4°C不冻结

1. Blades, H.Z., et al. Bone 47(5):989-994(2010). 2. Romero, R., et al. Am. J. Obstet. Gynecol. 203 (4), 361 (2010). 3. Jin, H., et al. Osteoporos Int (2010). 4. Szczesny, G., et al. Arch Orthop Trauma Surg (2010). 5. Cheung, M.S., et al. J. Bone Miner. Res. (2010)

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