抗体

CREBBP, NT(CREB结合蛋白, CREBBP, CBP, KAT3A)(APC)

034210-APC

200微升

711美元

多克隆

domestic rabbit

APC

CREBBP, NT(CREB结合蛋白, CREBBP, CBP, KAT3A)(APC)

兔

多克隆抗体

APC

抗体

200微升

711美元

IgG

CREBBP is an acetyltransferase enzyme that acetylates histones, giving a specific tag for transcriptional activation. It also acetylates non-histone proteins, like NCOA3 coactivator. This protein mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. CBP, as coactivator, augments the activity of phosphorylated CREB to activate transcription of cAMP-responsive genes. Chromosomal aberrations involving CREBBP may be a cause of acute myeloid leukemias. For example, MYST3-CREBBP may induce leukemia by inhibiting RUNX1-mediated transcription. Defects in CREBBP are also the cause of Rubinstein-Taybi syndrome (RSTS). RSTS is an autosomal dominant disorder characterized by craniofacial abnormalities, broad thumbs, broad big toes, mental retardation and a propensity for development of malignancies. Applications: Suitable for use in FLISA Recommended Dilution: FLISA: 1:1,000 Storage and Stability: Store product at 4°C in the dark. DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: APC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Note: Applications are based on unconjugated antibody.

Hu

CREB结合蛋白, CREBBP, CBP, KAT3A

CREBBP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 169~199 amino acids from the N-terminal region of human CREBBP.

人类

Purified by Protein G affinity chromatography.

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC).

As reported

Product Type: Pab Isotype: IgG Host: rabbit Source: human Concentration: As reported Form: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC). Purity: Purified by Protein G affinity chromatography. Immunogen: CREBBP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 169~199 amino acids from the N-terminal region of human CREBBP. Specificity: Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

FL

4°C不冻结

Cui, Q., et al., Oncogene 24(24):3864-3874 (2005). Gray, M.J., et al., Oncogene 24(19):3110-3120 (2005). Mayr, B.M., et al., J. Biol. Chem. 280(15):15103-15110 (2005). Roelfsema, J.H., et al., Am. J. Hum. Genet. 76(4):572-580 (2005). Furumatsu, T., et al., J. Biol. Chem. 280(9):8343-8350 (2005).