抗体

DNA topoisomerase II, CT (TOP2A, TOP2, DNA topoisomerase 2-alpha isozyme)

034689

200微升

569美元

多克隆

domestic rabbit

未共轭

DNA topoisomerase II, CT (TOP2A, TOP2, DNA topoisomerase 2-alpha isozyme)

兔

多克隆抗体

抗体

200微升

569美元

IgG

This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromosome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. Applications: Suitable for use in Western Blot, ELISA Recommended Dilution: ELISA: 1:1,000 Western Blot: 1:100-500 Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Hu

TOP2A, TOP2, DNA topoisomerase 2-alpha isozyme

TOP2A/Topo antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1433-1461 amino acids from the C-terminal region of human TOP2A/Topo?.

人类

Purified by Protein A affinity chromatography.

以溶解在PBS液体方式提供, pH值7.2, 0.09% 叠氮化钠

As reported

Product Type: Pab Isotype: IgG Host: rabbit Source: human Concentration: As reported Form: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide. Purity: Purified by Protein A affinity chromatography. Immunogen: TOP2A/Topo antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1433-1461 amino acids from the C-terminal region of human TOP2A/Topo?. Specificity: Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

E免疫印迹

-20°C

Vranic, S., et al. Hum. Pathol. 41(11):1617-1623(2010) Chen, H., et al. Am. J. Surg. Pathol. 34(9):1250-1257(2010) Ye, J., et al. Cell 142(2):230-242(2010) Rossi, E., et al. Histopathology 57(1):81-89(2010) Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)

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