产品简要
公司名称 :
US Biological
产品类型 :
抗体
产品名称 :
GNAS, CT (GNAS, GNAS1, Neuroendocrine secretory protein 55, LHAL tetrapeptide, GPIPIRRH peptide)
目录 :
036130
规格 :
200微升
价格 :
569美元
克隆性 :
多克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
反应物种 :
人类
更多信息或购买 :
产品信息
目录号 :
036130
Product wo Prefix :
GNAS, CT (GNAS, GNAS1, Neuroendocrine secretory protein 55, LHAL tetrapeptide, GPIPIRRH peptide)
宿主 :
产品类型 :
多克隆抗体
类别 :
抗体
尺寸1 :
200微升
Size1 List :
569美元
抗体亚型 :
IgG
Desc1 :
This locus has a highly complex imprinted expression pattern. It gives rise to maternally, paternally, and biallelically expressed transcripts that are derived from four alternative promoters and 5' exons. Some transcripts contains a differentially methylated region (DMR) at their 5' exons, and this DMR is commonly found in imprinted genes and correlates with transcript expression. An antisense transcript is produced from an overlapping locus on the opposite strand. One of the transcripts produced from this locus, and the antisense transcript, are paternally expressed noncoding RNAs, and may regulate imprinting in this region. In addition, one of the transcripts contains a second overlapping ORF, which encodes a structurally unrelated protein - Alex. Alternative splicing of downstream exons is also observed, which results in different forms of the stimulatory G-protein alpha subunit, a key element of the classical signal transduction pathway linking receptor-ligand interactions with the activation of adenylyl cyclase and a variety of cellular reponses. Multiple transcript variants encoding different isoforms have been found for this gene. Mutations in this gene result in pseudohypoparathyroidism type 1a, pseudohypoparathyroidism type 1b, Albright hereditary osteodystrophy, pseudopseudohypoparathyroidism, McCune-Albright syndrome, progressive osseus heteroplasia, polyostotic fibrous dysplasia of bone, and some pituitary tumors. Applications: Suitable for use in Western Blot, ELISA Recommended Dilution: ELISA: 1:1,000 Western Blot: 1:100-500 Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Calc Crossreactivity :
Hu
又名 :
GNAS, GNAS1, Neuroendocrine secretory protein 55, LHAL tetrapeptide, GPIPIRRH peptide
免疫原 :
KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 216-244aa in the C-terminal region of human GNAS, UniProt Accession #NP_057676.1; O95467
特异性 :
识别人类GNAS
纯度 :
Purified by Protein A affinity chromatography.
形式 :
以溶解在PBS液体方式提供, pH值7.2, 0.09% 叠氮化钠
浓度 :
As reported
Desc2 :
Product Type: Pab Isotype: IgG Host: rabbit Source: human Concentration: As reported Form: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide. Purity: Purified by Protein A affinity chromatography. Immunogen: KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 216-244aa in the C-terminal region of human GNAS, UniProt Accession #NP_057676.1; O95467 Specificity: Recognizes human GNAS. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Calc Applications Abbrev :
免疫印迹
储存温度 :
-20°C
参考文献 :
1. Idziaszczyk, S., et al. (2010)Cancer Genet. Cytogenet. 202(1):67-69. 2.Bailey, S.D., et al. (2010)Diabetes Care 33(10):2250-2253. 3.Tominaga, E., et al. (2010)Gynecol. Oncol. 118(2):160-166. 4.Park, C.H., et al. (2010)Ann. Clin. Lab. Sci. 40(3):261-266. 5.Cross, D.S., et al.(2010) BMC Genet. 11, 51.
Picture 1 File Name :
https://usbio-images.r.worldssl.net/prodimages/1/036130_1.jpg
更多信息或购买 :
公司信息
US Biological
4 Technology Way
Salem, MA01970
tech@usbio.net
https://www.usbio.net
800-520-3011 781-639-5092
公司总部: 美国
United States Biological是生命科学领域的知名品牌,致力于用真实、有价值的个性化采购经验降低研究用成本。