抗体

ITCH, ID (ITCH, E3 ubiquitin-protein ligase Itchy homolog, Atrophin-1-interacting protein 4, NFE2-associated polypeptide 1) (AP)

037130-AP

200微升

711美元

多克隆

domestic rabbit

AP

ITCH, ID (ITCH, E3 ubiquitin-protein ligase Itchy homolog, Atrophin-1-interacting protein 4, NFE2-associated polypeptide 1) (AP)

兔

多克隆抗体

AP

抗体

200微升

711美元

IgG

Atrophin-1 contains a polyglutamine repeat, expansion of which is responsible for dentatorubral and pallidoluysian atrophy. The protein encoded by this gene interacts with atrophin-1. This encoded protein is a closely related member of the NEDD4-like protein family. This family of proteins are E3 ubiquitin-ligase molecules and regulate key trafficking decisions, including targeting of proteins to proteosomes or lysosomes. This encoded protein contains four tandem WW domains and a HECT (homologous to the E6-associated protein carboxyl terminus) domain. It can act as a transcriptional corepressor of p45/NFE2 and may participate in the regulation of immune responses by modifying Notch-mediated signaling. It is highly similar to the mouse Itch protein, which has been implicated in the regulation and differentiation of erythroid and lymphoid cells. Applications: Suitable for use in Western Blot, ELISA Recommended Dilution: ELISA: 1:1,000 Western Blot: 1:100-500 Storage and Stability: Store product at 4°C. DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Note: Applications are based on unconjugated antibody.

Mo

ITCH, E3 ubiquitin-protein ligase Itchy homolog, Atrophin-1-interacting protein 4, NFE2-associated polypeptide 1

ITCH antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 508-536 amino acids from the Central region of human ITCH.

小鼠

Purified by Protein A affinity chromatography.

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phophatase (AP).

As reported

Product Type: Pab Isotype: IgG Host: rabbit Source: mouse Concentration: As reported Form: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phophatase (AP). Purity: Purified by Protein A affinity chromatography. Immunogen: ITCH antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 508-536 amino acids from the Central region of human ITCH. Specificity: Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

E免疫印迹

4°C不冻结

Yang, F., et al. Cell Death Differ. 17(8):1354-1367(2010) Baumann, C., et al. FEBS J. 277(13):2803-2814(2010) Venuprasad, K. Cancer Res. 70(8):3009-3012(2010) Lohr, N.J., et al. Am. J. Hum. Genet. 86(3):447-453(2010) Ushijima, Y., et al. Virol. J. 7, 179 (2010) :

https://usbio-images.r.worldssl.net/prodimages/9/037130-AP_1.jpg