产品简要
公司名称 :
US Biological
产品类型 :
抗体
产品名称 :
PTEN, CT (PTEN, MMAC1, TEP1, Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN, Mutated in multiple advanced cancers 1, Phosphatase and tensin homolog)
目录 :
040592
规格 :
200微升
价格 :
569美元
克隆性 :
多克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
反应物种 :
人类
更多信息或购买 :
产品信息
目录号 :
040592
Product wo Prefix :
PTEN, CT (PTEN, MMAC1, TEP1, Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN, Mutated in multiple advanced cancers 1, Phosphatase and tensin homolog)
宿主 :
产品类型 :
多克隆抗体
类别 :
抗体
尺寸1 :
200微升
Size1 List :
569美元
抗体亚型 :
IgG
Desc1 :
This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. Applications: Suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA. Other applications have not been tested. Recommended Dilutions: Western Blot: 1:1000 Immunofluorescence: 1:10-1:50 Immunohistochemistry (FFPE): 1:10-1:50 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Calc Crossreactivity :
Hu
又名 :
PTEN, MMAC1, TEP1, Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN, Mutated in multiple advanced cancers 1, Phosphatase and tensin homolog
免疫原 :
KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 306-335 in the C-terminal region of human PTEN, UniProt Accession #P60484. Species Sequence Homology: mouse and Xenopus
特异性 :
识别人类磷酸酶张力蛋白同源基因
纯度 :
Purified by Protein A affinity chromatography.
形式 :
以溶解在PBS液体方式提供, pH值7.2, 0.09% 叠氮化钠
浓度 :
As Reported
Desc2 :
Product Type: Pab Isotype: IgG Host: rabbit Source: human Concentration: As Reported Form: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide. Purity: Purified by Protein A affinity chromatography. Immunogen: KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 306-335 in the C-terminal region of human PTEN, UniProt Accession #P60484. Species Sequence Homology: mouse and Xenopus Specificity: Recognizes human PTEN. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Calc Applications Abbrev :
E IF免疫组化免疫印迹
储存温度 :
-20°C
参考文献 :
1. Miletic, A.V., et al. J. Exp. Med. 207(11):2407-2420(2010). 2. Kini, V., et al. J. Biol. Chem. 285(43):33082-33091(2010). 3. Shimada, M., et al. Hum. Genet. 128(4):433-441(2010). 4. Molina, J.R., et al. Cancer Res. 70(17):6697-6703(2010). 5. Iliopoulos, D., et al. Mol. Cell 39(4):493-506(2010)
Picture 1 File Name :
https://usbio-images.r.worldssl.net/prodimages/43/040592_1.jpg
更多信息或购买 :
公司信息
US Biological
4 Technology Way
Salem, MA01970
tech@usbio.net
https://www.usbio.net
800-520-3011 781-639-5092
公司总部: 美国
United States Biological是生命科学领域的知名品牌,致力于用真实、有价值的个性化采购经验降低研究用成本。