抗体

RASA1, CT (RASA1, RASA, Ras GTPase-activating protein 1, Ras p21 protein activator, p120GAP) (APC)

040842-APC

200微升

711美元

多克隆

domestic rabbit

APC

RASA1, CT (RASA1, RASA, Ras GTPase-activating protein 1, Ras p21 protein activator, p120GAP) (APC)

兔

多克隆抗体

APC

抗体

200微升

711美元

IgG

The protein encoded by this gene is located in the cytoplasm and is part of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. Mutations leading to changes in the binding sites of either protein are associated with basal cell carcinomas. Alternative splicing results in two isoforms where the shorter isoform, lacking the N-terminal hydrophobic region but retaining the same activity, appears to be abundantly expressed in placental but not adult tissues. Applications: Suitable for use in Western Blot and FLISA. Other applications have not been tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C before opening. DO NOT FREEZE! Stable at 4°C as an undiluted liquid. Dilute only prior to immediate use. Stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer. APC is light sensitive Note: Applications are based on unconjugated antibody.

Hu

RASA1, RASA, Ras GTPase-activating protein 1, Ras p21 protein activator, p120GAP

KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 966-993 in the C-terminal region of human RASA1, UniProt Accession #P20936.

识别人类RASA1

Purified by Protein A affinity chromatography.

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC).

As reported

Product Type: Pab Isotype: IgG Host: rabbit Source: human Concentration: As reported Form: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC). Purity: Purified by Protein A affinity chromatography. Immunogen: KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 966-993 in the C-terminal region of human RASA1, UniProt Accession #P20936. Specificity: Recognizes human RASA1. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

FL免疫印迹

4°C不冻结

Hemerly, J.P., et al. Eur. J. Endocrinol. 163(5):747-755(2010) Wiemels, J.L., et al. Blood Cells Mol. Dis. 45(3):186-191(2010) Bachas, C., et al. Blood 116(15):2752-2758(2010) Oinuma, I., et al. J. Biol. Chem. 285(36):28200-28209(2010) Anand, S., et al. Nat. Med. 16(8):909-914(2010)

https://usbio-images.r.worldssl.net/prodimages/5/040842-APC_1.jpg