抗体

YAP (S127) (YAP1, YAP65, Yorkie homolog, 65kD Yes-associated protein)

043943

200微升

569美元

多克隆

domestic rabbit

未共轭

YAP (S127) (YAP1, YAP65, Yorkie homolog, 65kD Yes-associated protein)

兔

多克隆抗体

抗体

200微升

569美元

IgG

Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Plays a key role to control cell proliferation in response to cell contact. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. The presence of TEAD transcription factors are required for it to stimulate gene expression, cell growth, anchorage-independent growth, and epithelial mesenchymal transition (EMT) induction. Isoform 2 and isoform 3 can activate the C-terminal fragment (CTF) of ERBB4 (isoform 3). Applications: Suitable for use in Dot Blot, ELISA Recommended Dilution: ELISA: 1:1,000 Dot Blot 1:500 Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Hu

YAP1, YAP65, Yorkie homolog, 65kD Yes-associated protein

Phospho-YAP-S127 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide between 119-133 amino acids surrounding S127 of human YAP.

人类

Purified by Protein A affinity chromatography.

以溶解在PBS液体方式提供, pH值7.2, 0.09% 叠氮化钠

As reported

Product Type: Pab Isotype: IgG Host: rabbit Source: human Concentration: As reported Form: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide. Purity: Purified by Protein A affinity chromatography. Immunogen: Phospho-YAP-S127 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide between 119-133 amino acids surrounding S127 of human YAP. Specificity: Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

DB E

-20°C

https://usbio-images.r.worldssl.net/prodimages/49/043943_1.jpg