产品简要
公司名称 :
US Biological
产品类型 :
抗体
产品名称 :
ATM (Serine-protein Kinase ATM, Ataxia Telangiectasia Mutated, A-T mutated)
目录 :
A4000-25W
规格 :
100微升
价格 :
493美元
克隆性 :
多克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
反应物种 :
人类
更多信息或购买 :
产品信息
目录号 :
A4000-25W
Product wo Prefix :
ATM (Serine-protein Kinase ATM, Ataxia Telangiectasia Mutated, A-T mutated)
宿主 :
产品类型 :
多克隆抗体
类别 :
抗体
尺寸1 :
100微升
Size1 List :
493美元
抗体亚型 :
IgG
Desc1 :
ATM is a 350-370kD member of the ATM subfamily, PI3/PI4-kinase family of enzymes. It is ubiquitously expressed, and serves as a DNA damage sensor. ATM is activated via autophosphorylation at double strand breaks. Following activation, multiple substrates are phosphorylated, including Chk2, and ATR is recruited and activated as part of an integrated repair circuit. Human ATM is 3056aa in length. It contains one FAT (focal adhesion targeting) domain aa1960-2566, a PI-3/PI-4 kinase catalytic domain aa2712-2962 and a second, C-terminal FAT domain aa3024-3056. There are at least six Ser and four Thr utilized phosphorylation sites, and one critical acetylation activation site at aa3016. There are at least four potential splice variants. One shows a Trp substitution for aa536-3056, a second contains an eight aa substitution for aa2506-3056, a third possesses a five aa substitution for aa1637-3056, while a fourth contains a premature truncation after aa2756. Over aa2138-2400, human ATM shares 82% aa identity with mouse ATM. Applications: Suitable for use in Western Blot and Immunoprecipitation. Other applications not tested. Recommended Dilution: Western Blot: 1:500-1:2000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Calc Crossreactivity :
Hu Mo
免疫原 :
Synthetic peptide corresponding to human Ataxia Telangiectasia Mutated (ATM).
特异性 :
Recognizes human ATM. Species Crossreactivity: mouse.
纯度 :
Purified by affinity chromatography.
形式 :
以溶解在PBS液体方式提供, 0.5% BSA, 0.01% 硫柳汞, 30% 甘油
浓度 :
未确定
Desc2 :
Product Type: Pab Isotype: IgG Host: rabbit Source: human Concentration: Not determined Form: Supplied as a liquid in PBS, 0.5% BSA, 0.01% thimerosal, 30% glycerol. Purity: Purified by affinity chromatography. Immunogen: Synthetic peptide corresponding to human Ataxia Telangiectasia Mutated (ATM). Specificity: Recognizes human ATM. Species Crossreactivity: mouse. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Calc Applications Abbrev :
免疫沉淀免疫印迹
储存温度 :
-20°C
更多信息或购买 :
公司信息
US Biological
4 Technology Way
Salem, MA01970
tech@usbio.net
https://www.usbio.net
800-520-3011 781-639-5092
公司总部: 美国
United States Biological是生命科学领域的知名品牌,致力于用真实、有价值的个性化采购经验降低研究用成本。