抗体

CTNNA1 (Catenin alpha-1, Alpha E-catenin, Cadherin-associated Protein, Renal Carcinoma Antigen NY-REN-13)

C2069-40R

100微克

532美元

多克隆

domestic goat

未共轭

人类, 小鼠, 大鼠

CTNNA1 (Catenin alpha-1, Alpha E-catenin, Cadherin-associated Protein, Renal Carcinoma Antigen NY-REN-13)

山羊

多克隆抗体

抗体

100微克

532美元

IgG

Three catenin proteins, a, b and y, bind to the highly conserved, intracellular cytoplasmic tail of E-cadherin. The catenin/cadherin complexes play an important role mediating cellular adhesion. Not only associated with E-cadherin, a-catenin was also shown to associate with other members of the cadherin family, such as Ncadherin and P-cadherin. b-catenin associates with the cytoplasmic portion of E-cadherin, which is necessary for the function of E-cadherin as an adhesion molecule. b-catenin has also been found in complexes with the tumor suppressor protein APC. y-catenin, also known as plakoglobin, is a protein that binds with a-catenin and N-cadherin. It has been shown that the transmembrane phosphatase PTP associates with catenin/cadherin complexes and may regulate complex signaling. Applications: Suitable for use in ELISA, Western Blot and Immunohistochemistry Other applications not tested. Recommended Dilution: ELISA: 1:32,000 Western Blot: 1-3ug/ml, observed in human colon and skin lysates on ~100kD bands Immunohistochemistry (Paraffin): 3-6mg/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Ca Hu Mo Rt

Synthetic peptide corresponding to C-KREKQDETQTKIK, from human CTNNA1, at the internal region of the protein (NP_001894.2).

Recognizes human CTNNA1. Species sequence homology: Canine, mouse and rat.

经免疫亲和层析纯化

Supplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.

~0.5毫克/毫升

Product Type: Pab Host: goat Source: human Concentration: ~0.5mg/ml Form: Supplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA. Purity: Purified by immunoaffinity chromatography. Immunogen: Synthetic peptide corresponding to C-KREKQDETQTKIK, from human CTNNA1, at the internal region of the protein (NP_001894.2). Specificity: Recognizes human CTNNA1. Species sequence homology: Canine, mouse and rat. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

E免疫组化免疫印迹

-20°C

1. Lynch HT, Grady W, Suriano G, Huntsman D. Gastric cancer: New genetic developments. J Surg Oncol. 2005 May 13;90(3):114-133.

https://usbio-images.r.worldssl.net/prodimages/18/C2069-40R_1.jpg