抗体

Cyclophilin A (Cyclosporin A Binding Protein, Peptidyl Prolyl Cis Trans Isomerase A, PPIASE)

C8850-03A

100微升

516美元

多克隆

domestic rabbit

未共轭

Cyclophilin A (Cyclosporin A Binding Protein, Peptidyl Prolyl Cis Trans Isomerase A, PPIASE)

兔

多克隆抗体

抗体

100微升

516美元

IgG

Cyclophilins are a highly conserved family of peptidylprolyl cis-trans-isomerases (PPIA) that are targets of the immunosuppressant drug cyclosporin A (CsA). The complex of cyclophilin and CsA can bind to and inhibit calcineurin which leads to inhibition of the transcription factor NFAT and decreased production of cytokines. As isomerases, cyclophilins have been proposed to aid in protein folding. Cyclophilin A can bind to the p55 Gag protein of HIV and appears necessary for HIV infection. There is also some evidence that cyclophilins can have nuclease activity and play a role in apoptosis. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilutions: Western Blot: 1:1000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Hu Mk Mo Rt

Synthetic peptide corresponding to residues near the C-terminus of Cyclophilin A. Species Sequence Homology: bovine and canine

Recognizes endogenous levels of total Cyclophilin A at ~18kD. Species Crossreactivity: human, mouse, rat and monkey.

Purified by Protein A and peptide affinity chromatography.

Supplied as a liquid in 10mM sodium HEPES, pH 7.5, 150mM sodium chloride, 0.1mg/ml BSA, 50% glycerol.

未确定

Product Type: Pab Isotype: IgG Host: rabbit Concentration: Not Determined Form: Supplied as a liquid in 10mM sodium HEPES, pH 7.5, 150mM sodium chloride, 0.1mg/ml BSA, 50% glycerol. Purity: Purified by Protein A and peptide affinity chromatography. Immunogen: Synthetic peptide corresponding to residues near the C-terminus of Cyclophilin A. Species Sequence Homology: bovine and canine Specificity: Recognizes endogenous levels of total Cyclophilin A at ~18kD. Species Crossreactivity: human, mouse, rat and monkey. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

免疫印迹

-20°C

1. Takahashi, N. et al. (1989) Nature 337, 473–475. 2. Wang, P. and Heitman, J. (2005) Genome Biol. 6, 226. 3. Jain, J. et al. (1993) Nature 365, 352–355. 4. McCaffrey, P.G. et al. (1993) J. Biol. Chem. 268, 3747–3752. 5. Thali, M. et al. (1994) Nature 372, 363–365. 6. Streblow, D.N. et al. (1998) Virology 245, 197–202. 7. Montague, J.W. et al. (1994) J. Biol. Chem. 269, 18877–18880.

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