产品简要
公司名称 :
US Biological
产品类型 :
抗体
产品名称 :
GFAP(胶质纤维酸性蛋白)
目录 :
G2032-27Q
规格 :
100微克
价格 :
532美元
克隆性 :
多克隆
宿主 :
domestic goat
共轭标签 :
未共轭
反应物种 :
人类, 小鼠, 大鼠
更多信息或购买 :
产品信息
目录号 :
G2032-27Q
Product wo Prefix :
GFAP(胶质纤维酸性蛋白)
宿主 :
山羊
产品类型 :
多克隆抗体
类别 :
抗体
尺寸1 :
100微克
Size1 List :
532美元
抗体亚型 :
IgG
Desc1 :
GFAP (Glial Fibrillary Acidic Protein) is a member of the intermediate filament protein family which includes desmin, peripherin and vimentin. It is a major protein component in multiple sclerosis plaques but is found to be up-regulated in other instances where there has been damage or the occurrence of disease to the nervous system. GFAP is expressed in cells of astrocytic lineage, peripheral ganglia, and non-myelinating Schwann cells. In addition, neural stem cells also express GFAP. GFAP runs on SDS-PAGE gels at ~55kD, usually associated with lower molecule weight bands which are thought to be proteolytic fragments and alternate transcripts from the single gene. Antibodies to GFAP are useful markers of astrocytic cells and neural stem cells. In addition many types of brain tumors, presumably derived from astrocytic cells, heavily express GFAP. Finally, Alexander's disease was recently shown to be caused by point mutations in protein coding region of the GFAP gene. All forms of Alexander disease are characterized by the presence of Rosenthal fibers, which are GFAP containing cytoplasmic inclusions found in astrocytes.
Applications:
Suitable for use in ELISA, Western Blot and Immunohistochemistry. Other applications not tested.
Recommended Dilution:
Peptide ELISA: 1:128,000
Western Blot: 0.01-0.03ug/ml, observed in human brain (cerebellum) and mouse brain lysates on ~48kD bands
Immunohistochemistry (paraffin): 2-4ug/ml
Immunohistochemistry (frozen): 0.01-0.03mg/ml
Optimal dilutions to be determined by the researcher.
Storage and Stability:
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Calc Crossreactivity :
Ca Hu Mo Rt
免疫原 :
Synthetic peptide corresponding to C-DGEVIKESKQEHKD, from the C-terminal of human GFAPl. Species sequence homology: canine, rat
特异性 :
Recognizes human GFAP. Species Crossreactivity: mouse
纯度 :
经免疫亲和层析纯化
形式 :
Supplied as a liquid in Tris saline, pH 7.3, 0.5% BSA, 0.02% sodium azide.
浓度 :
~0.5毫克/毫升
Desc2 :
Product Type: Pab
Isotype: IgG
Host: goat
Source: human
Concentration: ~0.5mg/ml
Form: Supplied as a liquid in Tris saline, pH 7.3, 0.5% BSA, 0.02% sodium azide.
Purity: Purified by immunoaffinity chromatography.
Immunogen: Synthetic peptide corresponding to C-DGEVIKESKQEHKD, from the C-terminal of human GFAPl. Species sequence homology: canine, rat
Specificity: Recognizes human GFAP. Species Crossreactivity: mouse
Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Calc Applications Abbrev :
E免疫组化免疫印迹
储存温度 :
-20°C
参考文献 :
1. Korolainen MA, Auriola S, Nyman TA, Alafuzoff I, Pirttila T. Proteomic analysis of glial fibrillary acidic protein in Alzheimer's disease and aging brain. Neurobiol Dis. 2005 Dec;20(3):858-70. Epub 2005 Jun 27.
Picture 1 File Name :
https://usbio-images.r.worldssl.net/prodimages/8/G2032-27Q_1.jpg
更多信息或购买 :
公司信息
US Biological
4 Technology Way
Salem, MA01970
Salem, MA01970
tech@usbio.net
https://www.usbio.net800-520-3011 781-639-5092
公司总部: 美国
United States Biological是生命科学领域的知名品牌,致力于用真实、有价值的个性化采购经验降低研究用成本。
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