产品简要
公司名称 :
US Biological
产品类型 :
抗体
产品名称 :
糖原合酶激酶3甲, 乙, 磷酸化(Ser21/9)(GSK3a, b)
目录 :
G8170-43B
规格 :
100微升
价格 :
566美元
克隆性 :
多克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
抗原修饰 :
磷酸化
反应物种 :
人类
更多信息或购买 :
产品信息
目录号 :
G8170-43B
Product wo Prefix :
糖原合酶激酶3甲, 乙, 磷酸化(Ser21/9)(GSK3a, b)
宿主 :
产品类型 :
多克隆抗体
抗原修饰 :
磷酸化
类别 :
抗体
尺寸1 :
100微升
Size1 List :
566美元
抗体亚型 :
IgG
Desc1 :
Glycogen synthase kinase 3 (GSK-3) was initially identified as an enzyme that regulates glycogen synthesis in response to insulin. GSK-3 is a ubiquitously expressed serine/threonine protein kinase that phosphorylates and inactivates glycogen synthase. GSK-3 is a critical downstream element of the PI3 kinase/Akt cell survival pathway, and its activity can be inhibited by Akt-mediated phosphorylation at Ser21 of GSK-3alpha and Ser9 of GSK-3beta. GSK-3 has been implicated in the regulation of cell fate in Dictyostelium and is a component of the Wnt signaling pathway required for Drosophila, Xenopus and mammalian development. GSK-3 has been shown to regulate cyclin D1 proteolysis and subcellular localization. Applications: Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilutions: Western Blot: 1:1000. Incubate membrane with diluted antibody in 5% BSA, 1X TBS, 0.1% Tween-20 at 4°C with gentle shaking, overnight. Immunohistochemistry (Paraffin): 1:50. Use citrate as unmasking buffer. Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Calc Crossreactivity :
Hu Mk Mo Rt
免疫原 :
Synthetic phosphopeptide corresponding to the sequence of human GSK-3 alpha.
特异性 :
Recognizes endogenous levels of human GSK-3 only when phosphorylated at Ser21 of GSK-3 alpha or Ser9 of GSK-3 beta. MW: ~46, 51kD. Species Crossreactivity: mouse, rat, monkey and zebrafish
纯度 :
Purified by Protein A and peptide affinity chromatography.
形式 :
Supplied as a liquid in 10mM HEPES, pH 7.5, 150mM sodium chloride, 0.1mg/ml BSA, 50% glycerol. No preservative added.
浓度 :
未确定
Desc2 :
Product Type: Pab Isotype: IgG Host: rabbit Source: human Concentration: Not Determined Form: Supplied as a liquid in 10mM HEPES, pH 7.5, 150mM sodium chloride, 0.1mg/ml BSA, 50% glycerol. No preservative added. Purity: Purified by Protein A and peptide affinity chromatography. Immunogen: Synthetic phosphopeptide corresponding to the sequence of human GSK-3 alpha. Specificity: Recognizes endogenous levels of human GSK-3 only when phosphorylated at Ser21 of GSK-3 alpha or Ser9 of GSK-3 beta. MW: ~46, 51kD. Species Crossreactivity: mouse, rat, monkey and zebrafish Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Calc Applications Abbrev :
免疫印迹
储存温度 :
-20°C
参考文献 :
1. Welsh, G. I. et al. (1996) Trends Cell. Biol. 6, 274–279. 2. Srivastava, A.K. and Pandey, S.K. (1999) Mol. Cell. Biochem. 182, 135–141. 3. Cross, D. A. et al. (1995) Nature 378, 785–789. 4. Nusse, R. (1997) Cell 89, 321–323. 5. Diehl, J. A. et al. (1998) Genes Dev. 12, 3499–3511.
Picture 1 File Name :
https://usbio-images.r.worldssl.net/prodimages/26/G8170-43B_1.jpg
更多信息或购买 :
公司信息
US Biological
4 Technology Way
Salem, MA01970
tech@usbio.net
https://www.usbio.net
800-520-3011 781-639-5092
公司总部: 美国
United States Biological是生命科学领域的知名品牌,致力于用真实、有价值的个性化采购经验降低研究用成本。