产品简要
公司名称 :
US Biological
产品类型 :
抗体
产品名称 :
MEK1 (MAPK/ERK Kinase 1, MEK 1, Dual Specificity Mitogen-Activated Protein Kinase Kinase 1, MAP Kinase Kinase 1, MAP2K1, MAPKK 1, MKK1, PRKMK1, ERK Activator Kinase 1)
目录 :
M2865-15C
规格 :
100微升
价格 :
516美元
克隆性 :
单克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
克隆名称 :
7H40(30C8)
反应物种 :
人类
更多信息或购买 :
产品信息
目录号 :
M2865-15C
Product wo Prefix :
MEK1 (MAPK/ERK Kinase 1, MEK 1, Dual Specificity Mitogen-Activated Protein Kinase Kinase 1, MAP Kinase Kinase 1, MAP2K1, MAPKK 1, MKK1, PRKMK1, ERK Activator Kinase 1)
宿主 :
产品类型 :
单克隆抗体
类别 :
抗体
尺寸1 :
100微升
Size1 List :
516美元
克隆#USB :
7H40(30C8)
抗体亚型 :
IgG
Desc1 :
MEK1 and MEK2, also called MAPK or Erk kinases, are dual-specificity protein kinases that function in a mitogen activated protein kinase cascade controlling cell growth and differentiation (1–3). Activation of MEK1 and MEK2 occurs through phosphorylation of two serine residues at positions 217 and 221 (in the activation loop of subdomain VIII) by Raf-like molecules. MEK1/2 is activated by a wide variety of growth factors and cytokines and also by membrane depolarization and calcium influx (1–4). Constitutively active forms of MEK1/2 are sufficient for the transformation of NIH/3T3 cells or the differentiation of PC12 cells (4). MEK activates p44 and p42 MAP kinase by phosphorylating both threonine and tyrosine residues at sites located within the activation loop of kinase subdomain VIII. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: Western blot 1:1000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. For long-term storage, store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Calc Crossreactivity :
Hu Mk Mo Rt
又名 :
丝裂原活化蛋白激酶激酶1, EC=2.7。 12.2
免疫原 :
合成多肽对应于人的MEK1
特异性 :
Detects endogenous levels of total human MEK1 protein. Does not crossreact with MEK2 and other MAPK kinases. Species Crossreactivity: mouse, monkey and rat
纯度 :
纯化
形式 :
Supplied as a liquid in 10mM HEPES, pH 7.5, 150mM sodium chloride, 0.1mg/ml BSA, <0.02% sodium azide, 50% glycerol.
浓度 :
未确定
Desc2 :
Product Type: Mab Isotype: IgG Clone No: 7H40(30C8) Host: rabbit Source: human Concentration: Not determined Form: Supplied as a liquid in 10mM HEPES, pH 7.5, 150mM sodium chloride, 0.1mg/ml BSA, <0.02% sodium azide, 50% glycerol. Purity: Purified Immunogen: Synthetic peptide corresponding to human MEK1. Specificity: Detects endogenous levels of total human MEK1 protein. Does not crossreact with MEK2 and other MAPK kinases. Species Crossreactivity: mouse, monkey and rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Calc Applications Abbrev :
E免疫印迹
储存温度 :
-20°C
参考文献 :
(1) Crews, C.M. et al. (1992) Science 258, 478–480. (2) Alessi, D.R. et al. (1994) EMBO J. 13, 1610–1619. (3) Rosen, L.B. et al. (1994) Neuron 12, 1207–1221. (4) Cowley, S. et al. (1994) Cell 77, 841–852.
Picture 1 File Name :
https://usbio-images.r.worldssl.net/prodimages/16/M2865-15C_1.jpg
更多信息或购买 :
公司信息
US Biological
4 Technology Way
Salem, MA01970
tech@usbio.net
https://www.usbio.net
800-520-3011 781-639-5092
公司总部: 美国
United States Biological是生命科学领域的知名品牌,致力于用真实、有价值的个性化采购经验降低研究用成本。