抗体

神经生长因子(神经生长因子)

N2050-03

100微升

516美元

多克隆

domestic rabbit

未共轭

神经生长因子(神经生长因子)

兔

多克隆抗体

抗体

100微升

516美元

IgG

Nerve growth factor (NGF) is a small, secreted protein and member of the neurotrophin family of growth factors that promote neuronal cell survival and differentiation (1). Producing cells release NGF that bind and activate TrkA high affinity receptors to mediate NGF-driven signaling. NGF also binds to a low affinity p75 (NTR) receptors, which belong to the death receptor family (2). Although NGF has been classically described as favoring neuron survival and differentiation, nerve growth factor can promote apoptosis in cells that contain p75 (NTR) and lack TrkA. NGF can induce neuron death in a variety of neurodegenerative conditions, including Alzheimer disease (3). Besides its neurotrophic actions, NGF has an effect on non-neuronal cells and may help mediate inflammation, angiogenesis, and stimulate breast cancer cell growth (4-6). NGF signaling is looking increasingly promising as potential drug targets for diseases. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1:1000 Optimal dilutions to be determined by the researcher. Storage and Stability: For long-term storage, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Hu

Synthetic peptide corresponding to residues surrounding Thr146 of human NGF (KLH).

Recognizes recombinant human NGF. It does not cross-react with other proteins.

经免疫亲和层析纯化

Supplied as a liquid in 10mM sodium HEPES, pH 7.5, 150mM sodium chloride, 100ug/ml BSA, 50% glycerol.

未确定

Product Type: Pab Isotype: IgG Host: rabbit Source: human Concentration: Not determined Form: Supplied as a liquid in 10mM sodium HEPES, pH 7.5, 150mM sodium chloride, 100ug/ml BSA, 50% glycerol. Purity: Purified by immunoaffinity chromatography. Immunogen: Synthetic peptide corresponding to residues surrounding Thr146 of human NGF (KLH). Specificity: Recognizes recombinant human NGF. It does not cross-react with other proteins. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

免疫印迹

-20°C

(1) Lessmann, V. et al. (2003) Prog Neurobiol 69, 341–74. (2) Neet, K.E. and Campenot, R.B. (2001) Cell Mol Life Sci 58, 1021–35. (3) Lorigados-Pedre, L. and Bergado-Rosado, J. Rev Neurol 38, 957–71. (4) Frossard, N. et al. (2004) Eur J Pharmacol 500, 453–65. (5) Nico, B. et al. (2007) Microvasc Res [Epub ahead of print]. (6) Descamps, S. et al. (2001) J Biol Chem 276, 17864–70.

https://usbio-images.r.worldssl.net/prodimages/38/N2050-03_1.jpg