抗体

Nna1 (Nervous system nuclear protein induced by axotomy 1, AGTPBP1, Cytosolic carboxypeptidase-1)

N2920

100微升

516美元

多克隆

domestic rabbit

未共轭

Nna1 (Nervous system nuclear protein induced by axotomy 1, AGTPBP1, Cytosolic carboxypeptidase-1)

兔

多克隆抗体

抗体

100微升

516美元

IgG

Nervous system nuclear protein induced by axotomy 1 (Nna1, AGTPBP1 or cytosolic carboxypeptidase-1) is related to zinc carboxypeptidases and contains an ATP/GTP binding motif, a basic and a bipartite nuclear localization signal. Nna1 expression is rapidly induced in motor neurons following axotomy and down-regulated following reinnervation, which is consistent with abundant Nna1 expression in differentiating neurons and the absence of Nna1 in CNS proliferative zones (1). Furthermore, Purkinje cell degeneration is characterized by adult onset neurodegeneration resulting from Nna1 gene mutations, implicating Nna1 in mechanisms common to degeneration and regeneration (2). Applications: Suitable for use in Western Blot and Immunoprecipitation. Other applications not tested. Recommended Dilution: Western Blot: 1:1000, incubate membrane with diluted antibody in 5% BSA, 1X TBS, 0.1% Tween-20 at 4°C with gentle shaking, overnight. Immunoprecipitation: 1:50 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Hu Mo Rt

Synthetic peptide corresponding to residues surrounding Asp1175 of human Nna1. Uniprot Accession: Q9UPW5

Recongnizes endogenous levels of total human Nna1. Species crossreactivity: mouse, rat.

Purified by Protein A and peptide affinity chromatography.

Supplied as a liquid in 10mM sodium HEPES, pH 7.5, 150mM sodium chloride, 0.1mg/ml BSA, 50% glycerol.

未确定

Product Type: Pab Isotype: IgG Host: rabbit Source: human Concentration: Not determined Form: Supplied as a liquid in 10mM sodium HEPES, pH 7.5, 150mM sodium chloride, 0.1mg/ml BSA, 50% glycerol. Purity: Purified by Protein A and peptide affinity chromatography. Immunogen: Synthetic peptide corresponding to residues surrounding Asp1175 of human Nna1. Uniprot Accession: Q9UPW5 Specificity: Recongnizes endogenous levels of total human Nna1. Species crossreactivity: mouse, rat. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

免疫沉淀免疫印迹

-20°C

1. Harris, A. et al. (2000) Mol Cell Neurosci 16, 578-96, 2. Fernandez-Gonzalez, A. et al. (2002) Science 295, 1904-6.

https://usbio-images.r.worldssl.net/prodimages/39/N2920_1.jpg