产品简要
公司名称 :
US Biological
产品类型 :
抗体
产品名称 :
NOTCH2 (Neurogenic Locus Notch Homolog Protein 2, Notch 2, hN2)
目录 :
N5375-16A
规格 :
100微克
价格 :
423美元
克隆性 :
多克隆
宿主 :
domestic goat
共轭标签 :
未共轭
反应物种 :
人类
更多信息或购买 :
产品信息
目录号 :
N5375-16A
Product wo Prefix :
NOTCH2 (Neurogenic Locus Notch Homolog Protein 2, Notch 2, hN2)
宿主 :
山羊
产品类型 :
多克隆抗体
类别 :
抗体
尺寸1 :
100微克
Size1 List :
423美元
抗体亚型 :
IgG
Desc1 :
Notch signaling plays a key role in the normal development of many tissues and cell types, through diverse effects on differentiation, survival, and/or proliferation that are highly dependent on signal strength and cellular context. Members of the Notch gene family encode transmembrane receptors that are critical for various cell fate decisions. Notch family members share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Multiple human notch proteins (NOTCH1, NOTCH2, NOTCH3 and NOTCH4) have been identified and they function as a receptors for membrane bound ligands. Notch signaling is also linked to tumorigenesis as first demonstrated by the identification of a recurrent t(7;9)(q34;q34.3) chromosomal translocation involving the human Notch1 gene that is found in a small subset of human pre-T-cell acute lymphoblastic leukemias (T-ALL). Since this discovery, aberrant Notch signaling has been suggested to be involved in a wide variety of human neoplasms. Applications: Suitable for use in ELISA. Other applications not tested. Recommended Dilution: ELISA: 1:16,000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Calc Crossreactivity :
Bo Ca Hu Mo Po Rt
免疫原 :
Synthetic peptide corresponding to C-ERTPSHSGHLQGEH, from NOTCH2, at the internal region of the protein (NP_077719.2).
特异性 :
Recognizes NOTCH2. Species sequence homology: Bovine, canine, human, mouse, porcine and rat.
纯度 :
经免疫亲和层析纯化
形式 :
Supplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.
浓度 :
~0.5毫克/毫升
Desc2 :
Product Type: Pab Host: goat Source: human Concentration: ~0.5mg/ml Form: Supplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA. Purity: Purified by immunoaffinity chromatography. Immunogen: Synthetic peptide corresponding to C-ERTPSHSGHLQGEH, from NOTCH2, at the internal region of the protein (NP_077719.2). Specificity: Recognizes NOTCH2. Species sequence homology: Bovine, canine, human, mouse, porcine and rat. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Calc Applications Abbrev :
E
储存温度 :
-20°C
参考文献 :
1. Schwarzmeier JD, Hubmann R, Duchler M, Jager U, Shehata M. Regulation of CD23 expression by Notch2 in B-cell chronic lymphocytic leukemia. Leuk Lymphoma. 2005 Feb;46(2):157-65.
更多信息或购买 :
公司信息
US Biological
4 Technology Way
Salem, MA01970
tech@usbio.net
https://www.usbio.net
800-520-3011 781-639-5092
公司总部: 美国
United States Biological是生命科学领域的知名品牌,致力于用真实、有价值的个性化采购经验降低研究用成本。