产品简要
公司名称 :
US Biological
产品类型 :
抗体
产品名称 :
Notch2 (Notch Homolog 2, Drosophila, hN2)
目录 :
N5375-18
规格 :
100微升
价格 :
516美元
克隆性 :
单克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
克隆名称 :
8A20(8A1)
反应物种 :
人类
更多信息或购买 :
产品信息
目录号 :
N5375-18
Product wo Prefix :
Notch2 (Notch Homolog 2, Drosophila, hN2)
宿主 :
产品类型 :
单克隆抗体
类别 :
抗体
尺寸1 :
100微升
Size1 List :
516美元
克隆#USB :
8A20(8A1)
抗体亚型 :
IgG
Desc1 :
Notch1 is a transmembrane protein functioning in development and the determination of cell-fate (1). During maturation, the notch molecule is cleaved by a furin-like convertase at its extracellular domain (2). Upon binding to a ligand such as Delta1, or upon extracellular calcium depletion, the carboxy-terminal notch1 fragment is released and further cleaved between Gly1743 and Val1744 (3,4). The resulting activated cytosolic fragment translocates to the nucleus where it activates transcription. Mutation in Notch2 is associated with Alagille syndrome (5). Applications: Suitable for use in Western Blot and Immunoprecipitation. Other applications have not been tested. Recommended Dilution: Western Blot: 1:1000 Immunoprecipitation: 1:50 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Calc Crossreactivity :
Hu
免疫原 :
Recombinant protein consisting of the heterodimerization domain of human Notch2.
特异性 :
Recognizes endogenous levels of total human Notch2 protein at ~230kD (extracellular domain, EC) and ~300kD (full length, FL).
纯度 :
纯化
形式 :
Supplied as a liquid in 10mM sodium HEPES, pH 7.5, 150mM sodium chloride, 0.1mg/ml BSA, 0.02% sodium azide, 50% glycerol.
浓度 :
未确定
Desc2 :
Product Type: Mab Isotype: IgG Clone No: 8A20(8A1) Host: rabbit Source: human Concentration: Not determined Form: Supplied as a liquid in 10mM sodium HEPES, pH 7.5, 150mM sodium chloride, 0.1mg/ml BSA, 0.02% sodium azide, 50% glycerol. Purity: Purified Immunogen: Recombinant protein consisting of the heterodimerization domain of human Notch2. Specificity: Recognizes endogenous levels of total human Notch2 protein at ~230kD (extracellular domain, EC) and ~300kD (full length, FL). Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Calc Applications Abbrev :
免疫沉淀免疫印迹
储存温度 :
-20°C
参考文献 :
1. Artavanis-Tsakonas, S., et al., Science 284: 770-776 (1999). 2. Chan, Y.M. & Jan, Y.N., Cell 94: 423-426 (1998). 3. Schroeter, E.H., et al., Nature 393: 382-386 (1998). 4. Rand, M.D., et al., Mol. Cell. Biol. 20: 1825-1835 (2000). 5. McDaniell, R., et al., Am. J. Hum. Genet. 79: 169-173 (2006).
Picture 1 File Name :
https://usbio-images.r.worldssl.net/prodimages/33/N5375-18_1.jpg
更多信息或购买 :
公司信息
US Biological
4 Technology Way
Salem, MA01970
tech@usbio.net
https://www.usbio.net
800-520-3011 781-639-5092
公司总部: 美国
United States Biological是生命科学领域的知名品牌,致力于用真实、有价值的个性化采购经验降低研究用成本。