抗体

Nucleophosmin (NPM, NPM1, Nucleolar Phosphoprotein B23, Nucleolar Protein NO38, Numatrin, NPM)

N7100-14

100微克

532美元

多克隆

domestic goat

未共轭

Nucleophosmin (NPM, NPM1, Nucleolar Phosphoprotein B23, Nucleolar Protein NO38, Numatrin, NPM)

山羊

多克隆抗体

抗体

100微克

532美元

IgG

Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. Binds ribosome presumably to drive ribosome nuclear export. Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. Acts as a chaperonin for the core histones H3, H2B and H4. Stimulates APEX1 endonuclease activity on apurinic/apyrimidinic (AP) double-stranded DNA but inhibits APEX1 endonuclease activity on AP single-stranded RNA. May exert a control of APEX1 endonuclease activity within nucleoli devoted to repair AP on rDNA and the removal of oxidized rRNA molecules. In concert with BRCA2, regulates centrosome duplication. Regulates centriole duplication: phosphorylation by PLK2 is able to trigger centriole replication. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: ELISA: 1:2000 Western Blot: 0.1-0.3ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Bo Ca Hu Mo Rt

Synthetic peptide corresponding to C-QEAIQDLWQWRKSL, from NPM1, at C-terminal (NP_002511.1, NP_954654.1).

Recognizes human NPM1. Species Crossreactivity: Mouse and rat. Species sequence homology: Bovine and canine.

经免疫亲和层析纯化

Supplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.

~0.5毫克/毫升

Product Type: Pab Host: goat Source: human Concentration: ~0.5mg/ml Form: Supplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA. Purity: Purified by immunoaffinity chromatography. Immunogen: Synthetic peptide corresponding to C-QEAIQDLWQWRKSL, from NPM1, at C-terminal (NP_002511.1, NP_954654.1). Specificity: Recognizes human NPM1. Species Crossreactivity: Mouse and rat. Species sequence homology: Bovine and canine. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

E免疫印迹

-20°C

1. Grisendi S, Pandolfi PP. NPM mutations in acute myelogenous leukemia. N Engl J Med. 2005 Jan 20;352(3):291-2.

https://usbio-images.r.worldssl.net/prodimages/46/N7100-14_1.jpg