抗体

Snail

S1014-67H

100微升

516美元

单克隆

大鼠

未共轭

SN9H2

Snail

大鼠

单克隆抗体

抗体

100微升

516美元

SN9H2

IgG

Snail is a zinc-finger transcription factor that can repress E-cadherin transcription. Down regulation of E-cadherin is associated with epithelial-mesenchymal transition during embryonic development, a process also exploited by invasive cancer cells (1-3). Indeed, loss of E-cadherin expression is correlated with the invasive properties of some tumors and there is a considerable inverse correlation between Snail and E-cadherin mRNA levels in epithelial tumor cell lines (4,5). In addition, Snail blocks the cell cycle and confers resistance to cell death (6). Phosphorylation of Snail by GSK3 and PAK1 regulates its stability, cellular localization and function (7-10). Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot 1:1000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. For long-term storage, store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Hu Mk

Recombinant protein corresponding to human Snail protein.

Detects the endogenous levels of total human Snail. Species Crossreactivity: monkey

腹水

Supplied as a liquid in 10mM HEPES, pH 7.5, 150mM sodium chloride, 100ug/ml BSA, <0.02% sodium azide, 50% glycerol.

未确定

Product Type: Mab Isotype: IgG Clone No: SN9H2 Host: rat Source: human Concentration: Not determined Form: Supplied as a liquid in 10mM HEPES, pH 7.5, 150mM sodium chloride, 100ug/ml BSA, <0.02% sodium azide, 50% glycerol. Purity: Ascites. Immunogen: Recombinant protein corresponding to human Snail protein. Specificity: Detects the endogenous levels of total human Snail. Species Crossreactivity: monkey Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

免疫印迹

-20°C

(1) Barrallo-Gimeno, A. and Nieto, M.A. (2005) Development 132, 3151–61. (2) Cano, A. et al. (2000) Nat. Cell Biol. 2, 76–83. (3) Batlle, E. et al. (2000) Nat. Cell Biol. 2, 84–89. (4) Yokoyama, K. et al. (2003) Int. J. Oncol. 22, 891–898. (5) Yokoyama, K. et al. (2001) Oral Oncol. 37, 65–71. (6) Vega, S. et al. (2004) Genes Dev. 18, 1131–1143. (7) Zhou, B.P. et al. (2004) Nat. Cell Biol. 6, 931–940. (8) Bachelder, R.E. et al. (2005) J. Cell Biol. 168, 29–33. (9) Yook, J.I. et al. (2005) J. Biol. Chem. 280, 11740–11748. (10) Yang, Z. et al. (2005) Cancer Res. 65, 3179–3184.

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