抗体

Tyk2, phosphorylated (Tyr1054/1055) (Non-receptor Tyrosine Kinase)

T9220-02

100微升

566美元

多克隆

domestic rabbit

未共轭

磷酸化

Tyk2, phosphorylated (Tyr1054/1055) (Non-receptor Tyrosine Kinase)

兔

多克隆抗体

磷酸化

抗体

100微升

566美元

IgG

Tyk2, a member of the Jak family of protein tyrosine kinases, associates with and is activated by receptors for many cytokines including IL-13, the IL-6 family, IL-10, and interferon-alpha and beta. Following ligand binding, Tyk2 is activated by phosphorylation on Tyr1054 and/or Tyr1055. Tyk2 is required for the tyrosine phosphorylation of Stat3 in the IFN-beta signaling cascade. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilutions: Western Blot: 1:1000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Hu

Synthetic phosphopeptide corresponding to residues surrounding tyrosine 1054/1055 of human Tyk2. Species Sequence Homology: mouse and rat

Recognizes endogenous levels of human Tyk2 only when phosphorylated at tyrosine1054/1055 at 134kD. Does not detect other sites of tyrosine phosphorylation on Tyk2.

Purified by Protein A and peptide affinity chromatography.

Supplied as a liquid in 10mM HEPES, pH 7.5, 150mM sodium chloride, 0.1mg/ml BSA, 50% glycerol. No preservative added.

未确定

Product Type: Pab Isotype: IgG Host: rabbit Source: human Concentration: Not Determined Form: Supplied as a liquid in 10mM HEPES, pH 7.5, 150mM sodium chloride, 0.1mg/ml BSA, 50% glycerol. No preservative added. Purity: Purified by Protein A and peptide affinity chromatography. Immunogen: Synthetic phosphopeptide corresponding to residues surrounding tyrosine 1054/1055 of human Tyk2. Species Sequence Homology: mouse and rat Specificity: Recognizes endogenous levels of human Tyk2 only when phosphorylated at tyrosine1054/1055 at 134kD. Does not detect other sites of tyrosine phosphorylation on Tyk2. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

E免疫印迹

-20°C

1. Velazquez, L. et al. (1995) J. Biol. Chem. 270, 3327–3334. 2. Stahl, N. et al. (1994) Science 263, 92–95. 3. Leonard, W.J. (1998) Annu. Rev. Immunol. 16, 293–322. 4. Grauzzi, M.C. et al. (1996) J. Biol. Chem. 271, 20494–20500. 5. Rani, M.R. et al. (1999) J. Biol. Chem. 274, 32507–32511.

https://usbio-images.r.worldssl.net/prodimages/44/T9220-02_1.jpg