产品简要
公司名称 :
武汉菲恩生物科技
产品类型 :
抗体
产品名称 :
淀粉样蛋白前体小鼠单克隆
目录 :
FNab00513
规格 :
100微克
价格 :
245USD
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
反应物种 :
man
应用 :
免疫印迹, 酶联免疫吸附测定
更多信息或购买 :
产品信息
目录代码 :
FNab00513
产品名称 :
淀粉样蛋白前体小鼠单克隆
产品类型 :
抗体
宿主物种 :
小鼠
克隆性 :
单克隆
共轭 :
未共轭
抗体亚型 :
IgG2a
规格 :
100微克
标价 :
245USD
背景 :
Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1-KAT5 and inhibits Notch signaling through interaction with Numb. Couples to apoptosis-inducing pathways such as those mediated by G(O) and JIP. Inhibits G(o) alpha ATPase activity (By similarity). Acts as a kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1. Involved in copper homeostasis/oxidative stress through copper ion reduction. In vitro, copper-metallated APP induces neuronal death directly or is potentiated through Cu(2+)-mediated low-density lipoprotein oxidation. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I and IV. The splice isoforms that contain the BPTI domain possess protease inhibitor activity. Induces a AGER- dependent pathway that involves activation of p38 MAPK, resulting in internalization of amyloid-beta peptide and leading to mitochondrial dysfunction in cultured cortical neurons. Provides Cu(2+) ions for GPC1 which are required for release of nitric oxide (NO) and subsequent degradation of the heparan sulfate chains on GPC1. Beta-amyloid peptides are lipophilic metal chelators with metal-reducing activity. Bind transient metals such as copper, zinc and iron. In vitro, can reduce Cu(2+) and Fe(3+) to Cu(+) and Fe(2+), respectively. Beta-amyloid 42 is a more effective reductant than beta-amyloid 40. Beta-amyloid peptides bind to lipoproteins and apolipoproteins E and J in the CSF and to HDL particles in plasma, inhibiting metal-catalyzed oxidation of lipoproteins. Beta-APP42 may activate mononuclear phagocytes in the brain and elicit inflammatory responses. Promotes both tau aggregation and TPK II-mediated phosphorylation. Interaction with overexpressed HADH2 leads to oxidative stress and neurotoxicity. Also binds GPC1 in lipid rafts. Appicans elicit adhesion of neural cells to the extracellular matrix and may regulate neurite outgrowth in the brain. The gamma-CTF peptides as well as the caspase-cleaved peptides, including C31, are potent enhancers of neuronal apoptosis. N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6).
别名 :
A4抗体, AD1抗体, 淀粉样蛋白前体抗体
产品描述 :
APP antibody: Mouse Monoclonal antibody to APP
免疫原 :
amyloid beta (A4) precursor protein
特异性 :
人类, 猪
纯度 :
≥95% as determined by SDS-PAGE
应用摘要 :
酶联免疫吸附测定, 免疫印迹
储存 :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
更多信息或购买 :
公司信息
武汉菲恩生物科技
武汉市东湖高新区高新大道666号光谷生物城创新园C6328
fine@fn-test.com
http://www.fn-test.cn
86-27-87384275
公司总部: 中国