抗体

CSK小鼠单克隆

FNab02017

100微克

245USD

单克隆

小鼠

未共轭

免疫印迹, 酶联免疫吸附测定, 免疫细胞化学

CSK小鼠单克隆

抗体

小鼠

单克隆

未共轭

IgG1

100微克

245USD

Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T- cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK.

CSK抗体

CSK antibody: Mouse Monoclonal antibody to CSK

c Src酪氨酸激酶

人类

≥95% as determined by SDS-PAGE

酶联免疫吸附测定, 免疫印迹, IF

PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)