抗体

CTNNA1小鼠单克隆

FNab02056

100微克

275USD

单克隆

小鼠

未共轭

免疫印迹, 酶联免疫吸附测定, 免疫组化

CTNNA1小鼠单克隆

抗体

小鼠

单克隆

未共轭

IgG1

100微克

275USD

Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. May play a crucial role in cell differentiation.

CTNNA1抗体

CTNNA1 antibody: Mouse Monoclonal antibody to CTNNA1

catenin (cadherin-associated protein), alpha 1, 102kDa

人类, 小鼠

≥95% as determined by SDS-PAGE

酶联免疫吸附测定, 免疫印迹, 免疫组化

PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)