产品简要
公司名称 :
武汉菲恩生物科技
产品类型 :
抗体
产品名称 :
缺氧诱导因子1A兔多克隆
目录 :
FNab03859
规格 :
100微克
价格 :
245USD
克隆性 :
多克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
反应物种 :
man
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化, 免疫细胞化学, 流式细胞仪
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产品信息
目录代码 :
FNab03859
产品名称 :
缺氧诱导因子1A兔多克隆
产品类型 :
抗体
宿主物种 :
兔
克隆性 :
多克隆
共轭 :
未共轭
抗体亚型 :
IgG
规格 :
100微克
标价 :
245USD
背景 :
Functions as a master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Binds to core DNA sequence 5′-[AG]CGTG-3′ within the hypoxia response element (HRE) of target gene promoters. Activation requires recruitment of transcriptional coactivators such as CREBPB and EP300. Activity is enhanced by interaction with both, NCOA1 or NCOA2. Interaction with redox regulatory protein APEX seems to activate CTAD and potentiates activation by NCOA1 and CREBBP. Involved in the axonal distribution and transport of mitochondria in neurons during hypoxia.
别名 :
BHLHE78抗体, MOP1抗体, PASD8抗体, 缺氧诱导因子1A抗体
产品描述 :
HIF1a antibody: Rabbit Polyclonal antibody to HIF1a
免疫原 :
hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
特异性 :
人类, 小鼠, 大鼠
纯度 :
≥95% as determined by SDS-PAGE
应用摘要 :
酶联免疫吸附测定, 免疫组化, IF, FC, 免疫印迹
储存 :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
更多信息或购买 :
公司信息
武汉菲恩生物科技