抗体

P21;CDKN1A兔多克隆

FNab06067

100微克

245USD

多克隆

domestic rabbit

未共轭

免疫印迹, 酶联免疫吸附测定, 免疫组化, 免疫细胞化学

P21;CDKN1A兔多克隆

抗体

兔

多克隆

未共轭

IgG

100微克

245USD

CDKN1A (p21, CIP1, WAF1) is a cyclin-dependent kinase inhibitor. CDKN1A binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at the G1 phase. The expression of CDKN1A is induced by wild-type but not mutant p53 protein, through which CDKN1A mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. CDKN1A can interact with proliferating cell nuclear antigen (PCNA), and plays a regulatory role in S phase DNA replication and DNA damage repair. CDKN1A was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation. Two alternatively spliced variants, which encode an identical protein, have been reported.

P21;CDKN1A抗体

P21;CDKN1A antibody: Rabbit Polyclonal antibody to P21;CDKN1A

cyclin-dependent kinase inhibitor 1A (p21, Cip1)

人类, 小鼠, 大鼠

≥95% as determined by SDS-PAGE

酶联免疫吸附测定, 免疫组化, IF, 免疫印迹

PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)