抗体

Anti-EGFR In Vivo Antibody - Low Endotoxin (EGFR.1) [ICH1021] ichorbio

ICH1021

1毫克

80 GBP

单克隆

小鼠

未共轭

表皮生长因子受体.1

ICH1021

Anti-EGFR In Vivo Antibody - Low Endotoxin (EGFR.1) [ICH1021] ichorbio

Anti-EGFR In Vivo Antibody - Low Endotoxin (EGFR.1) [ICH1021]

Bulk anti-EGFR In Vivo Antibody - Low Endotoxin (EGFR.1)

ichorbio's anti-EGFR In Vivo Antibody - Low Endotoxin (EGFR.1) is manufactured in a cGMP compliant, ISO Quality Standard 9001:2015 facility. ichorbio's low endotoxin antibodies have half the endotoxin of comparable antibodies from our competitors at less than 1.0 EU/mg. If ichorbio's low endotoxin antibodies are not low enough we also offer ultra low endotoxin antibodies which have even less endotoxin ( here for more information. ichorbio: the best antibodies for in vivo research.

表皮生长因子受体

表皮生长因子受体.1

1毫克

80 GBP

5mg

240

25mg

640

50mg

1040

100mg

1600

小鼠IgG2b

Epidermal growth factor receptor, Proto-oncogene c-ErbB-1, Receptor tyrosine-protein kinase erbB-1, ERBB, ERBB1, HER1

P00533

小鼠

人类

Anti-EGFR In Vivo Antibody - Low Endotoxin (EGFR.1) recognizes the (Mr 170 kDa) extracellular domain of the epidermal growth factor receptor on many cell surfaces. The EGFR mediates the initial response of cells to EGF. It has an extracellular region which binds EGF and an intracellular region which exhibits tyrosine kinase activity. The receptor phosphorylates a number of protein substrates in addition to mediating autophosphorylation

The epidermal growth factor receptor (EGFR; ErbB-1; HER1 in humans) is the cell-surface receptor for members of the epidermal growth factor family (EGF-family) of extracellular protein ligands. The epidermal growth factor receptor is a member of the ErbB family of receptors, a subfamily of four closely related receptor tyrosine kinases: EGFR (ErbB-1), HER2/c-neu (ErbB-2), Her 3 (ErbB-3) and Her 4 (ErbB-4). Mutations affecting EGFR expression or activity could result in cancer. EGFR (epidermal growth factor receptor) exists on the cell surface and is activated by binding of its specific ligands, including epidermal growth factor and transforming growth factor A (TGFA) (note, a full list of the ligands able to activate EGFR and other members of the ErbB family is given in the ErbB article). ErbB2 has no known direct activating ligand, and may be in an activated state constitutively or become active upon heterodimerization with other family members such as EGFR. Upon activation by its growth factor ligands, EGFR undergoes a transition from an inactive monomeric form to an active homodimer - although there is some evidence that preformed inactive dimers may also exist before ligand binding. In addition to forming homodimers after ligand binding, EGFR may pair with another member of the ErbB receptor family, such as ErbB2/Her2/neu, to create an activated heterodimer. There is also evidence to suggest that clusters of activated EGFRs form, although it remains unclear whether this clustering is important for activation itself or occurs subsequent to activation of individual dimers.

A431培养细胞

1.0-5.0毫克/毫升

0.01 M phosphate buffered saline (PBS) pH 7.2, 150 mM NaCl with no carrier protein, potassium or preservatives added. BSA and Azide free.

>95% by SDS-PAGE and HPLC

≤ 1.0 EU/mg as determined by the LAL method

Aggregation level ≤ 5%

anti-EGFR In Vivo Antibody - Low Endotoxin (EGFR.1) is stable when stored at 2-8°C. Do not freeze.

免疫印迹

Each investigator should determine their own optimal working dilution for specific applications.

Mouse IgG2b Isotype Control for In Vivo - Low Endotoxin [MPC-11] (ICH2250)

Anti-EGFR In Vivo Antibody - Ultra Low Endotoxin [EGFR.1] (ICH1021UL)

Products are for research use only. Not for use in diagnostic or therapeutic procedures.

Contact for industrial pricing