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Anti-CD154 In Vivo Antibody - Low Endotoxin (FGK4.5) [ICH1073] ichorbio

ICH1073

1毫克

80 GBP

单克隆

大鼠

未共轭

FGK4.5

ICH1073

Anti-CD154 In Vivo Antibody - Low Endotoxin (FGK4.5) [ICH1073] ichorbio

Anti-CD154 In Vivo Antibody - Low Endotoxin (FGK4.5) [ICH1073]

Bulk anti-CD154 In Vivo Antibody - Low Endotoxin (FGK4.5)

ichorbio's anti-CD154 In Vivo Antibody - Low Endotoxin (FGK4.5) is manufactured in a cGMP compliant, ISO Quality Standard 9001:2015 facility. ichorbio's low endotoxin antibodies have half the endotoxin of comparable antibodies from our competitors at less than 1.0 EU/mg. If ichorbio's low endotoxin antibodies are not low enough we also offer ultra low endotoxin antibodies which have even less endotoxin ( here for more information. ichorbio: the best antibodies for in vivo research.

CD154

FGK4.5

1毫克

80 GBP

5mg

240

25mg

640

50mg

1040

100mg

1600

大鼠IgG2a

CD40 ligand, Cd40lg, T-cell antigen Gp39, TNF-related activation protein, TRAP, Tnfsf5

P27548

大鼠

小鼠

Anti-CD154 In Vivo Antibody - Low Endotoxin (FGK4.5) recognizes an epitope on Mouse CD40

This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.

B cells, basal epithelial cells, macrophages, follicular dendritic cells, and endothelial cells

CD40, also known as TNFSF5, is a type I transmembrane protein and member of the TNF receptor family. The binding of CD40L (CD154) on TH cells to CD40 activates antigen presenting cells and induces a variety of downstream effects. CD40 is expressed on B cells, dendritic cells, monocytes, thymic epithelial cells and, at low levels, on T cells. Signaling though CD40 plays an important role in the proliferation and differentiation of B cells and is critical for immunoglobulin (Ig) class switching. The membrane-anchored CD40L is expressed almost exclusively on activated CD4+ T lymphocytes. Failure to express CD40L leads to "immunodeficiency with hyper-IgM", a disease characterized by failure to produce IgG, IgA and IgE. Some of the early intracellular signaling by the CD4-CD40L system includes the association of the CD40 with TRAFs and the activation of various kinases (4). Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of CD4-CD40L is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis.

重组小鼠CD40融合蛋白

1.0-5.0毫克/毫升

0.01 M phosphate buffered saline (PBS) pH 7.2, 150 mM NaCl with no carrier protein, potassium or preservatives added BSA and Azide free.

>95% by SDS-PAGE and HPLC

<0.5 EU/mg as determined by the LAL method

Aggregation level ≤ 5%

anti-CD154 In Vivo Antibody - Low Endotoxin (FGK4.5) is stable for at least one week when stored sterile at 2-8°C. For long term storage aseptically aliquot in working volumes without diluting and store at –80°C. Avoid Repeated Freeze Thaw Cycles.

Western Blot, Functional Assays

Each investigator should determine their own optimal working dilution for specific applications.

Rat IgG2a In Vivo Isotype Control - Low Endotoxin [1-1] (ICH2244)

Anti-CD154 In Vivo Antibody - Ultra Low Endotoxin [FGK4.5] (ICH1073UL)

Products are for research use only. Not for use in diagnostic or therapeutic procedures.

Contact for industrial pricing