产品简要
公司名称 :
ichorbio
产品类型 :
抗体
产品名称 :
Anti-CD154 In Vivo Antibody - Ultra Low Endotoxin (FGK4.5) [ICH1073UL] ichorbio
目录 :
ICH1073UL
规格 :
5毫克
价格 :
312 GBP
克隆性 :
单克隆
宿主 :
大鼠
共轭标签 :
未共轭
克隆名称 :
FGK4.5
反应物种 :
小鼠
应用 :
免疫印迹
更多信息或购买 :
ichorbio 产品网页
产品信息
产品类型 :
Ultra Low Endotoxin
ichorbio Cat Number :
ICH1073UL
Page Title :
Anti-CD154 In Vivo Antibody - Ultra Low Endotoxin (FGK4.5) [ICH1073UL] ichorbio
Page Heading :
Anti-CD154 In Vivo Antibody - Ultra Low Endotoxin (FGK4.5) [ICH1073UL]
Page Heading :
Bulk anti-CD154 In Vivo Antibody - Ultra Low Endotoxin (FGK4.5)
Product Benefits :
ichorbio's anti-CD154 In Vivo Antibody - Ultra Low Endotoxin (FGK4.5) is manufactured in a cGMP compliant, ISO Quality Standard 9001:2015 facility. This means that ichorbio's ultra low-endoxin antibodies have the lowest endotoxin in the industry at less than 0.75 EU/mg. The purity of ichorbio's ultra low endotoxin antibodies are unsurpassed at >98% and they are all pathogen tested and third-party certified by IDEXX BioReseach of meet the lowest mycoplasma specification and free of any viral pathogens of concern. ichorbio offers Amazon vouchers or donations to the NC3Rs for reviews of this product: click here for more information. ichorbio: the best antibodies for in vivo research.
靶标 :
CD154
克隆 :
FGK4.5
尺寸1 :
5毫克
Academic Price1 :
312 GBP
尺寸2 :
25mg
Academic Price2 :
832
Size3 :
50mg
Academic Price3 :
1352
Size4 :
100mg
Academic Price4 :
2080
抗体亚型 :
大鼠IgG2a
其他名称 :
CD40 ligand, Cd40lg, T-cell antigen Gp39, TNF-related activation protein, TRAP, Tnfsf5
UniProt数据库 :
P27548
宿主 :
大鼠
物种活性 :
小鼠
特异性 :
Anti-CD154 In Vivo Antibody - Ultra Low Endotoxin (FGK4.5) recognizes an epitope on Mouse CD40
纯化方法 :
This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.
Antigen Distribution :
B cells, basal epithelial cells, macrophages, follicular dendritic cells, and endothelial cells
背景 :
CD40, also known as TNFSF5, is a type I transmembrane protein and member of the TNF receptor family. The binding of CD40L (CD154) on TH cells to CD40 activates antigen presenting cells and induces a variety of downstream effects. CD40 is expressed on B cells, dendritic cells, monocytes, thymic epithelial cells and, at low levels, on T cells. Signaling though CD40 plays an important role in the proliferation and differentiation of B cells and is critical for immunoglobulin (Ig) class switching. The membrane-anchored CD40L is expressed almost exclusively on activated CD4+ T lymphocytes. Failure to express CD40L leads to "immunodeficiency with hyper-IgM", a disease characterized by failure to produce IgG, IgA and IgE. Some of the early intracellular signaling by the CD4-CD40L system includes the association of the CD40 with TRAFs and the activation of various kinases (4). Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of CD4-CD40L is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis.
免疫原 :
重组小鼠CD40融合蛋白
浓度 :
> 2.0 mg/ml
配方 :
0.01 M phosphate buffered saline (PBS) pH 7.2, 150 mM NaCl with no carrier protein, potassium or preservatives added. BSA and Azide free.
纯度 :
>98% by SDS-PAGE and HPLC
内毒素 :
≤ 0.75 EU/mg as determined by the LAL method
Aggregation :
Aggregation level ≤ 1%
IMPACT Pathogen Test :
We use the IMPACT test generated by IDEXX Laboratories to guarantee our Ultra Low Endotoxin antibodies are pathogen free. Our rat antibodies are tested for: Mycoplasma spp Mycoplasma pulmonis Pneumonia virus of mice Kilham's rat virus Toolan's H1 virus Rat parvovirus Lymphocytic choriomeningitis virus Rat cytomegalovirus Sendai virus Rat coronavirus Sialodacryoadenitis virus Rat minute virus Seoul virus Mouse adenovirus Reovirus 3 Rat theilovirus
储存 :
anti-CD154 In Vivo Antibody - Ultra Low Endotoxin (FGK4.5) is stable for at least four (4) weeks when stored sterile at 2-8°C. For long term storage aseptically aliquot in working volumes without diluting and store at –80°C. Avoid Repeated Freeze Thaw Cycles.
应用 :
Western Blot, Functional Assays
应用注释 :
Each investigator should determine their own optimal working dilution for specific applications.
Isotype Control :
Rat IgG2a In Vivo Isotype Control - Ultra Low Endotoxin [1-1] (ICH2244UL)
Related Antibody :
Anti-CD154 In Vivo Antibody - Low Endotoxin [FGK4.5] (ICH1073)
Antibodies against the same target :
Anti-CD154 In Vivo Antibody - Low Endotoxin [MR1] (ICH1072) , Anti-CD154 In Vivo Antibody - Ultra Low Endotoxin [MR1] (ICH1072UL)
Use :
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
价格说明 :
Contact for industrial pricing
更多信息或购买 :
ichorbio 产品网页
公司信息
ichorbio
Grove Business Park
Downsview Road
Wantage OX12 9FF
hello@ichor.bio
https://www.ichor.bio
公司总部: 英国