产品简要
公司名称 :
ichorbio
产品类型 :
抗体
产品名称 :
Anti-PD-1 In Vivo Antibody - Ultra Low Endotoxin (RMP1-14) [ICH1132UL] ichorbio
目录 :
ICH1132UL
规格 :
5毫克
价格 :
312 GBP
克隆性 :
单克隆
宿主 :
大鼠
共轭标签 :
未共轭
克隆名称 :
RMP1-14
反应物种 :
小鼠
应用 :
免疫印迹, 中和反应
更多信息或购买 :
ichorbio 产品网页
产品信息
产品类型 :
Ultra Low Endotoxin
ichorbio Cat Number :
ICH1132UL
Page Title :
Anti-PD-1 In Vivo Antibody - Ultra Low Endotoxin (RMP1-14) [ICH1132UL] ichorbio
Page Heading :
Anti-PD-1 In Vivo Antibody - Ultra Low Endotoxin (RMP1-14) [ICH1132UL]
Page Heading :
Bulk anti-PD-1 In Vivo Antibody - Ultra Low Endotoxin (RMP1-14)
Product Benefits :
ichorbio's anti-PD-1 In Vivo Antibody - Ultra Low Endotoxin (RMP1-14) is manufactured in a cGMP compliant, ISO Quality Standard 9001:2015 facility. This means that ichorbio's ultra low-endoxin antibodies have the lowest endotoxin in the industry at less than 0.75 EU/mg. The purity of ichorbio's ultra low endotoxin antibodies are unsurpassed at >98% and they are all pathogen tested and third-party certified by IDEXX BioReseach of meet the lowest mycoplasma specification and free of any viral pathogens of concern. ichorbio offers Amazon vouchers or donations to the NC3Rs for reviews of this product: click here for more information. ichorbio: the best antibodies for in vivo research.
靶标 :
PD-1
克隆 :
RMP1-14
尺寸1 :
5毫克
Academic Price1 :
312 GBP
尺寸2 :
25mg
Academic Price2 :
832
Size3 :
50mg
Academic Price3 :
1352
Size4 :
100mg
Academic Price4 :
2080
抗体亚型 :
大鼠IgG2a
其他名称 :
Programmed cell death protein 1, Pdcd1, CD279
UniProt数据库 :
Q02242
宿主 :
大鼠
物种活性 :
小鼠
特异性 :
Anti-PD-1 In Vivo Antibody - Ultra Low Endotoxin (RMP1-14) recognizes an epitope on Mouse PD-1
纯化方法 :
This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.
Antigen Distribution :
Subset of double negative thymocytes, activated T and B cells
背景 :
CD279, also known as programmed death-1 (PD-1) is a 50-55 kD immunoglobulin superfamily member. PD-1 is expressed on a subset of CD4-CD8- thymocytes, and on activated T and B cells. The PD-1 ligands, PD-L1 (also known as B7-H1) and PD-L2 (B7-DC), are members of the B7 immunoglobulin superfamily. This RMP1-14 antibody has been reported to block the binding of PD-1 to its ligands (B7-H1 and B7-DC) and to inhibit T cell proliferation and cytokine production.
免疫原 :
Mouse PD-1 transfected BHK cells
浓度 :
≥ 2.0 mg/ml
配方 :
0.01 M phosphate buffered saline (PBS) pH 7.2, 150 mM NaCl with no carrier protein, potassium or preservatives added. BSA and Azide free.
纯度 :
>98% by SDS-PAGE and HPLC
内毒素 :
≤ 0.75 EU/mg as determined by the LAL method
Aggregation :
Aggregation level ≤ 1%
IMPACT Pathogen Test :
We use the IMPACT test generated by IDEXX Laboratories to guarantee our Ultra Low Endotoxin antibodies are pathogen free. Our rat antibodies are tested for: Mycoplasma spp Mycoplasma pulmonis Pneumonia virus of mice Kilham's rat virus Toolan's H1 virus Rat parvovirus Lymphocytic choriomeningitis virus Rat cytomegalovirus Sendai virus Rat coronavirus Sialodacryoadenitis virus Rat minute virus Seoul virus Mouse adenovirus Reovirus 3 Rat theilovirus
储存 :
anti-PD-1 In Vivo Antibody - Ultra Low Endotoxin (RMP1-14) is stable when stored at 2-8°C. For long term storage aseptically aliquot in working volumes without diluting and store at –80°C. Avoid Repeated Freeze Thaw Cycles.
应用 :
Western Blot, Blocking, Functional Assays
应用注释 :
Blocking: Clone RMP1-14 antibody has been shown to block the binding of both mouse PD-L1-Ig and mouse PD-L2-Ig to PD-1. For immune checkpoint antibodies 200 ug per mouse per injection is the standard dosage in the literature. For this anti-PD-1 (clone RMP1-14), we suggest to inject 200 ug/mouse ip generally on days 3, 6 and 9, post injection of tumor. Sometime up to six injections depending on the length of the experiment may be required. Each investigator should determine their own optimal working dilution for specific applications.
Isotype Control :
Rat IgG2a In Vivo Isotype Control - Ultra Low Endotoxin [1-1] (ICH2244UL)
Related Antibody :
Anti-PD-1 In Vivo Antibody - Low Endotoxin [RMP1-14] (ICH1132)
Antibodies against the same target :
Anti-PD-1 In Vivo Antibody - Low Endotoxin [J43] (ICH1116) , Anti-PD-1 In Vivo Antibody - Low Endotoxin [29F.1A12] (ICH1091) , Anti-PD-1 In Vivo Antibody - Ultra Low Endotoxin [29F.1A12] (ICH1091UL)
Use :
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
价格说明 :
Contact for industrial pricing
更多信息或购买 :
ichorbio 产品网页
公司信息
ichorbio
Grove Business Park
Downsview Road
Wantage OX12 9FF
hello@ichor.bio
https://www.ichor.bio
公司总部: 英国