A compilation of immunohistochemical markers for all major cell types, excluding neural cells.
内皮细胞形成所有血管的内表面,从最大的动脉和静脉到毛细血管。有许多特有的和非特有的内皮标记已经得到确定。
特有的内皮细胞标记包括血管性血友病因子 [1] ,血管内皮细胞钙粘蛋白(VE-cadherin,CD144) [2] ,血栓调节蛋白(CD141) [3] 和Pathologische Anatomie Leiden-内皮(PAL-E) [4] 。重要的是,PAL-E作为血管内皮细胞的特异性标记,可用于区分血管内皮和淋巴管内皮细胞。此外,MECA-79和达菲抗原趋化因子受体(DARC)被证明是内皮细胞的高度特异性标记物 [1] 。
非特异性的内皮细胞标志包括血小板/ EC粘附分子-1(PECAM-1,CD31),血管内皮生长因子受体(VEGFRs):1型血管内皮生长因子受体(Flt-1),2型血管内皮生长因子受体(KDR/FLK-1),以及3型血管内皮生长因子受体,CD146(MUC-18,S- endo),UEA-1(荆豆I型凝集素)和eNOS(内皮一氧化氮合酶)。
还有一些其他标记,包括CD146(MUC-18,S-endo),血栓调节蛋白(CD141),ICAM-1(细胞粘附因子,CD54)和E-选择素(CD62E),这些标记对内皮细胞活化有重要作用 [5].
蛋白 | 蛋白序列号 | 基因序列号 | 数量 | 前三大供应商 |
---|---|---|---|---|
血小板/ EC粘附分子-1(PECAM-1, CD31) | P16284 | 5175 | 108 | BD Biosciences (44), Dako (32), Santa Cruz Biotechnology (8) |
血管性血友病因子 | P04275 | 7450 | 25 | Dako (18), Sigma-Aldrich (2), AbD Serotec (1) |
ICAM-1 (细胞间粘附因子, CD54) | P05362 | 3383 | 18 | Beckman Coulter, Inc. (3), BD Biosciences (3), Life Technologies Corporation (2) |
血管内皮钙粘蛋白 (VE-cadherin, CD144) | P33151 | 1003 | 16 | BD Biosciences (4), Santa Cruz Biotechnology (3), EMD Millipore (3) |
2型血管内皮生长因子受体(KDR/Flk-1) | P35968 | 3791 | 15 | Santa Cruz Biotechnology (6), BD Biosciences (3), Sigma-Aldrich (3) |
UEA-1(荆豆I型凝集素) | P08174 | 1604 | 11 | AbD Serotec (3), Santa Cruz Biotechnology (2), Beckman Coulter, Inc. (2) |
1型血管内皮生长因子受体(Flt-1) | P17948 | 2321 | 10 | Santa Cruz Biotechnology (7), R and D Systems (1), WILEX Inc. (1) |
eNOS (内皮一氧化氮合酶) | P29474 | 4846 | 10 | BD Biosciences (5), Cell Signaling Technology (2), Santa Cruz Biotechnology (1) |
3型血管内皮生长因子受体 | P35916 | 2324 | 8 | Santa Cruz Biotechnology (3), EMD Millipore (1), eBioscience (1) |
血栓调节蛋白(CD141) | P07204 | 7056 | 4 | BD Biosciences (1), Dako (1) |
CD146 (MUC-18, S-endo) | P43121 | 4162 | 4 | Enzo Life Sciences (1), EMD Millipore (1), Santa Cruz Biotechnology (1) |
E-选择素 (CD62E) | P16581 | 6401 | 2 | R and D Systems (1), BD Biosciences (1) |
Pathologische Anatomie Leiden-内皮 (PAL-E) | ||||
MECA-79 | ||||
达菲抗原趋化因子受体(DARC) | Q16570 | 2532 |
上皮细胞(EpC)来源于所有胚层(外胚层,内胚层和中胚层)。表皮细胞有外胚层来源的。占主导地位的表皮细胞是角质细胞,从表皮干细胞分化而来。有大量上皮亚型的特异性标记。
角蛋白(K)是含角蛋白的蛋白质,在上皮细胞细胞质中发现 [6, 7] 。有酸性的I型角蛋白和碱性的II型角蛋白。角蛋白1-3由鳞状上皮细胞表达。角蛋白5和角蛋白6由间皮细胞特异性表达,而角蛋白7由导管和腺上皮细胞特异性表达。 角蛋白8则在消化道上皮中表达(包括胃,大肠,小肠,胆,肝,胰腺)和乳腺导管 [8] 。皮肤和角质上皮细胞表达以下特定标记物:角蛋白1,5,10,14,15和16。 角蛋白10在鳞状上皮基底层表达。 角蛋白18作为恶性上皮细胞增殖的标记 [9].
蛋白 | 蛋白序列号 | 基因序列号 | 数量 | 前三大供应商 |
---|---|---|---|---|
钙粘蛋白 | P12830 | 999 | 66 | BD Biosciences (24), Life Technologies Corporation (13), Santa Cruz Biotechnology (7) |
角蛋白1 | P04264 | 3848 | 26 | Dako (6), Sigma-Aldrich (4), BD Biosciences (3) |
角蛋白7 | P08729 | 3855 | 26 | Dako (20), Santa Cruz Biotechnology (1), BD Biosciences (1) |
上皮膜抗原(EMA, CD227, MUC-1) | P15941 | 4582 | 21 | Dako (9), Leica Microsystems (3), Thermo Scientific Pierce Products (2) |
角蛋白18 | P05783 | 3875 | 19 | Sigma-Aldrich (6), Life Technologies Corporation (2), Roche Applied Science (2) |
存活素 | O15392 | 332 | 18 | Novus Biologicals (7), Abcam (2), Santa Cruz Biotechnology (2) |
细胞间黏附分子-1 | P05362 | 3383 | 18 | Beckman Coulter, Inc. (3), BD Biosciences (3), Life Technologies Corporation (2) |
角蛋白14 | P02533 | 3861 | 16 | Leica Microsystems (4), Covance (4), EMD Millipore (2) |
角蛋白5 | P13647 | 3852 | 15 | Dako (5), BD Biosciences (2), Leica Microsystems (2) |
角蛋白8 | P05787 | 3856 | 12 | Developmental Studies Hybridoma Bank (3), BD Biosciences (3), Dako (2) |
VLA-6 | P23229 | 3655 | 12 | EMD Millipore (5), Beckman Coulter, Inc. (2), BD Biosciences (2) |
粘附分子LFA-1 | P20701 | 3683 | 9 | BD Biosciences (3), ATCC (2), Life Technologies Corporation (1) |
粘附分子LFA-2 | P06729 | 914 | 9 | BD Biosciences (4), Leica Microsystems (2), Stemcell Technologies (2) |
角蛋白10 | P13645 | 3858 | 8 | Dako (3), Covance (2), Thermo Scientific Pierce Products (1) |
前列腺特异性抗原(PSA) | P07288 | 354 | 8 | Dako (4), Beckman Coulter, Inc. (1), Abcam (1) |
VLA-5 | P08648 | 3678 | 7 | EMD Millipore (4), Santa Cruz Biotechnology (2), Beckman Coulter, Inc. (1) |
免疫球蛋白G的Fc段 (FcR) | P12318 | 2212 | 6 | BD Biosciences (2), AbD Serotec (1), Stemcell Technologies (1) |
VLA-3 | P26006 | 3675 | 6 | EMD Millipore (3), Beckman Coulter, Inc. (1), Dako (1) |
表面活化蛋白A | Q8IWL2 | 653509 | 5 | Dako (3), EMD Millipore (2) |
VLA-2 | P17301 | 3673 | 5 | BD Biosciences (2), Beckman Coulter, Inc. (1), EMD Millipore (1) |
VLA-4 | P13612 | 3676 | 3 | Beckman Coulter, Inc. (1), EMD Millipore (1), eBioscience (1) |
角蛋白 3 | P12035 | 3850 | 2 | Santa Cruz Biotechnology (1), BD Biosciences (1) |
角蛋白 16 | P08779 | 3868 | 2 | Leica Microsystems (2) |
上皮钠离子通道alpha | P37088 | 6337 | 2 | Abcam (1), EMD Millipore (1) |
表面活化蛋白C | P11686 | 6440 | 2 | EMD Millipore (2) |
角蛋白 15 | P19012 | 3866 | 1 | Covance (1) |
上皮钠离子通道delta | P51172 | 6339 | 1 | Thermo Scientific Pierce Products (1) |
表面活化蛋白B | P07988 | 6439 | 1 | Dako (1) |
整合素分子VLA-1 | P56199 | 3672 | 1 | Beckman Coulter, Inc. (1) |
角蛋白 2 | P35908 | 3849 | ||
角蛋白 6 | P02538 | 3853 | ||
上皮钠离子通道beta | P51168 | 6338 | ||
上皮钠离子通道gamma | P51170 | 6340 | ||
表面活化蛋白D | P35247 | 6441 |
上皮细胞的其他标记还包括钙粘蛋白,上皮细胞膜抗原(EMA,CD227,MUC-1)(大多数分泌内皮型上皮细胞表达),上皮钠离子通道α, β, γ, δ,前列腺特异性抗原(PSA)(前列腺上皮细胞表达),表面活化蛋白A-D(肺上皮细胞表达),存活素(细胞上皮癌)。
此外,它们还表达IgG的Fc部分(FcR),整合素分子:VLA-1,2,3,4,5,6,粘附分子LFA-1,LFA-2,ICAM-1[1548035)。这些形成消化道内层的细胞由内胚层分化而来。体腔内层由中胚层分化形成。
树突状细胞(DC)在包括抗原特异性免疫的获得性免疫中发挥了关键作用。根据功能和位置,树突状细胞可划分为三个亚群:常规树突细胞,浆细胞样树突状细胞和真皮(皮肤上)树突细胞 [10].
常规树突细胞驻留在淋巴结,脾脏和胸腺内。在小鼠中,常规树突细胞可分为CD8 +(表型CD8+ CD205+ SIRPA CD11b在脾中和CD11chiMHC II+CD8+CD205+在淋巴结中)和CD8-树突状细胞 [11] 。这些细胞激活T细胞向Th1和Th2分化。
浆细胞样树突状细胞(pDC)属于树突状细胞的第二大类,它驻留在淋巴结,脾,胸腺和骨髓中。人的浆细胞样树突状细胞在骨髓中分化成熟,通过分泌抗病毒和促炎症细胞因子,包括干扰素,肿瘤坏死因子alpha,IL-6和IL-12,在抗病毒免疫中发挥特定角色。这些细胞由两个亚群构成:CD2高和CD2低浆细胞样树突状细胞。人类和小鼠的浆细胞样树突状细胞表达以下标记:B220/CD45R,CD11c [12] ,TLR7和TLR9,IRF7,IRF8 [13] ,以及BDCA2 [14] 。
树突状细胞的第三大亚群位于皮肤上,由骨髓发展而来。皮肤树突状细胞有两个不同的小的亚群:表皮朗格汉斯细胞(LC)和真皮树突状细胞。表皮朗格汉斯细胞通过包含凝集素的伯贝克颗粒的存在和表达以下标记鉴定:CD1a、CD45。此外,真皮树突状细胞的两个小亚群已经确定:CD103+CD11b低凝集素+和CD103CD11b高凝集素的树突状细胞 [15] 。真皮树突状细胞也表达CD14。成熟的树突状细胞也表达CD1a、CD1b和CD1C分子,代表对CD1/限制T细胞的脂质和糖脂抗原 [16] 。
有几个调节树突状细胞分化的因子已被确定。与GMC-SF + IL4共培养,人CD14+单核细胞分化成树突状细胞 [17] 。此外,与GMC-SF + TNF共培养,人CD34+细胞也可以分化成树突状细胞 [18] 。小鼠骨髓细胞与GMCSF + TNF +干细胞因子(SCF]共培养可以分化成树突状细胞 [19] 。
还有一些其他的树突状细胞的标记,它们有不同程度的特异性。CD83是成熟树突状细胞的一个特异性分子标记 [20] 。CD21和丛生蛋白是滤泡树突状细胞的标记 [21, 22] 。此外,树突状细胞表达: ADAM19 [23], CD86 [24], DC-LAMP (CD208] [25, 26], DC-SIGN (CD209) [27], DEC-205 [28], CLIP-170/休眠蛋白 [29], NLDC-145 [30] 。MADDAM (金属蛋白酶和解聚素树突状抗原标记)是树突细胞分化的一个标记 [31] 。
神经胶质细胞是存在于神经系统中,为神经元提供保护和营养,调控早期发育中神经元迁移,以及神经元和神经递质释放之间的通信的细胞。胶质细胞谱系包括小神经胶质细胞和大胶质细胞。人类小胶质细胞在骨髓中由造血干细胞分化而来和表达MHC I类分子, MHC II类分子,CD45,CD68,和S22 [32] 。
大胶质细胞由星形胶质细胞,少突胶质细胞,室管膜细胞,放射状胶质细胞,施旺细胞,卫星细胞和肠道神经胶质细胞构成。星形胶质细胞可分为1型星形胶质细胞(RAN2+,GFAP+,FGFR3+ A2B5)和2型星形胶质细胞(A2B5+,GFAP+,FGFR3,Ran2-)。施旺细胞主要有两大类:髓鞘(特异性标志物:S-100蛋白,髓鞘蛋白零(P-Zero)和髓鞘碱性蛋白(MBP))和非髓鞘(特异性标志物:S-100和胶质纤维酸性蛋白(GFAP))。少突胶质前体表达血小板衍生生长因子(PDGF)受体,与PDGF结合 [33] 。室管膜细胞表达S-100,波形蛋白,GFAP,BLBP,3A7和3CB2 [34] 。施旺细胞是外周神经系统的主要神经胶质细胞。识别施旺细胞的特异性标记为S-100,髓鞘碱性蛋白(MBP),髓鞘蛋白零(MPZ)。卫星细胞在周围神经系统中为神经元提供支持,并表达CD45和骨髓系统标记CD14,CD68和CD11b [35] 。肠神经胶质细胞的特异性标志物包括:S-100蛋白,神经丝蛋白和蛋白基因产物9.5(PGP) [36] 。
骨髓包含造血干细胞(HSC),产生的血细胞主要有三大类:白细胞,红细胞和血小板。人类造血干细胞的主要表型是: CD34+, CD38low/-, CD59+, Thy1+, c-Kit+, Lin-。小鼠的造血干细胞可鉴定为: CD34low/-, CD38+, Thy1+/low, SCA-1+, c-Kit+, Lin-。造血干细胞表达的其他标记有: CD90, CD93, CD105, CD110, Ly-6A/E (Sca-1), CD111, CD135 (Flk-2), CD150 (SLAM), CD184 (CXCR4), CD202b, CD243 (MDR-1), CD271 (NFGR), CD309 (VEGFR2) and CD338 [37] 。
骨髓中分化的主要流程包括骨髓细胞生成,红细胞生成和巨核细胞系的发育。骨髓细胞生成过程,产生下面几种类型的细胞:粒细胞,单核细胞和肥大细胞。有三种类型的粒细胞在骨髓中生成:嗜酸性粒细胞,嗜碱性粒细胞和嗜中性粒细胞。在IL-3,IL-5和GM-CSF刺激下嗜酸性粒细胞从骨髓中分化 [38-40] 。小鼠和人的嗜中性粒细胞表达下列标记分子:FcεRI, CD123, CD49b (DX-5), CD69, Thy-1.2, 2B4, CD11bdull [41], Ly-6G [42] 。单核细胞的特定表面标记为CD14 (CD14+细胞)。骨髓肥大细胞持续表达的标记包括: CD9, CD29, CD33, CD43, CD44, CD49d, CD49e, CD51, CD71, CD117和Fc(epsilon)RI [43] 。
Natural Killer (NK) cells play the important role in immune response against malignant and infected cells. During NK lineage development, human NK cells pass through five main stages of differentiation. During these five stages NK cells express distinct sets of markers
自然杀伤细胞(NK)在恶性病毒侵袭和受感染细胞的免疫反应中发挥重要作用。 自然杀伤细胞谱系生成过程中,人类自然杀伤细胞经过了五个主要分化阶段。在这五个阶段中自然杀伤细胞表达不同的标记分子: 1) CD34+CD45RA+CD117−CD161−CD94−; 2) CD34+CD45RA+CD117+CD161+/−CD94−; 3) CD34−CD117+CD161+NKp46−CD94−; 4) CD34−CD117+/−NKp46+CD94+CD16−CD56bright; 5) CD34−CD117−NKp46+CD94+/−CD16+CD56dim [44] 。根据CD56 [45, 46] 和低亲和Fc受体CD16表面表达强度,人类血液自然杀伤细胞有两个主要的类群。大量CD56dim自然杀伤细胞(~90%) 表达高水平的CD16,而少量CD56bright自然杀伤细胞表达有限的CD16。
与人类自然杀伤细胞相比,小鼠的自然杀伤细胞亚群可通过CD27和CD11b标记来区分。这些亚群包括不成熟的CD11b 自然杀伤细胞,CD27+自然杀伤细胞,CD27+自然杀伤细胞和成熟的(最终)CD27CD11b+ 自然杀伤细胞。自然杀伤细胞能够被多种白细胞介素激活:IL-12, IL-2, IL-15, IL-18。并且,自然杀伤细胞表达CXC, CC和C趋化因子受体,这在调节自然杀伤细胞功能中非常重要 [47] 。此外,自然杀伤细胞表达受体识别MHC I类分子(人KIRs, 啮齿类Ly49和CD94/NKG2),NKp46, FcgRII 和非MHC结合自然杀伤细胞受体 (NKR-P1 (CD161)) [48],自然细胞毒受体 (NCR)和2B4) [49], NKG2A和NKp80 [50], CD107a-标记有功能的自然杀伤细胞活性 [51], CD69 –自然杀伤细胞活性标记 [48], CD335/NKp46 [52], BAT [53], CD57/HNK1 [54], NKH1 (N901) [55], DPIV (二肽基肽酶IV)-自然杀伤细胞的一个表面标记 [56], H25 [57] 。
蛋白 | 详细 | 蛋白序列号 | 基因序列号 | 数量 | 前三大供应商 | ||
---|---|---|---|---|---|---|---|
Th1细胞 | |||||||
CD4 | 细胞表面 [58] | P01730 | 920 | 109 | BD (61), Leica/Novocastra (11), Beckman (8) | ||
TNFalpha | 分泌 | P01375 | 7124 | 64 | BD (18), R & D (14), Life Tech/Biosource (8) | ||
IFN-gamma | 分泌 | P01579 | 3458 | 58 | BD (25), Thermo Fisher/Endogen (9), R & D (4) | ||
CD195 | 细胞表面 [58] | P51681 | 1234 | 27 | BD (14), R & D (8), Berlex Biosciences (2) | ||
CCR5 | 趋化因子 [59, 60] | P51681 | 1234 | 27 | BD (14), R & D (8), Berlex Biosciences (2) | ||
CXCR3 | 趋化因子受体 [59, 60] | P49682 | 2833 | 9 | R & D (5), BD (4) | ||
CD183 | 细胞表面 [58] | P49682 | 2833 | 9 | R & D (5), BD (1) | ||
CD119 | 细胞表面 [58] | P15260 | 3459 | 4 | Thermo Fisher (1), AbD Serotec (1), SCBT (1) | ||
CD26 | 细胞表面 [58] | P27487 | 1803 | 4 | eBioscience/Bender (1), Enzo/Biomol (1), Ancell (1) | ||
CD94 | 细胞表面 [58] | Q13241 | 3824 | 3 | BD (3) | ||
CCR1 | 细胞表面 [58] | P32246 | 1230 | 3 | MBL (1), Capralogics (1), GEnzyme (1) | ||
IL-18R | 细胞表面 [58] | Q13478 | 8809 | 2 | BD, R & D | ||
LT-betaR | 细胞表面 [58] | P36941 | 4055 | 1 | SCBT | ||
Tim-3 | 细胞表面 [58] | Q8TDQ0 | 84868 | 0 | |||
TNFbeta | 分泌 | P01374 | 4049 | 0 | |||
Tbet | 转录因子 [61] | Q9UL17 | 30009 | 0 | |||
Th2 cells | |||||||
CD4 | 细胞表面 [58] | P01730 | 920 | 109 | BD (61), Leica/Novocastra (11), Beckman (8) | ||
CD184/CXCR4 | 趋化因子, 趋化因子受体 [58, 59, 62] | P61073 | 7852 | 28 | R & D (12), BD (7), EMD Millipore (2) | ||
IL-10 | 分泌 | P22301 | 3586 | 25 | BD (13), R & D (6), eBioscience (3) | ||
IL-4 | 分泌 | P05112 | 3565 | 16 | BD (9), R & D (2), Thermo Fisher/Endogen (1 | ||
IL-13 | 分泌 | P35225 | 3596 | 9 | BD (3), R & D (2), Thermo Fisher/Affinity Bioreagents (1) | ||
CD197/CCR7 | 趋化因子, 趋化因子受体 [58, 59, 62] | P32248 | 1236 | 8 | BD (4), R & D (2), eBioscience (1) | ||
IL-5 | 分泌 | P05113 | 3567 | 7 | BD (20), R & D (1), Life Tech/Biosource (1) | ||
CD193/CCR3 | 趋化因子, 趋化因子受体 [58, 59, 62] | P51677 | 1232 | 6 | SCBT (2), R & D (2), NIH AID repository (1) | ||
IFNalphaR/TNFR-I | 细胞表面 [58] | P19438 | 7132 | 5 | R & D (3), Life Tech/Caltag (1), Genzyme (1) | ||
CD194/CCR4 | 趋化因子, 趋化因子受体 [58, 59, 62] | P51679 | 1233 | 3 | BD (2), SCBT (1) | ||
CD278/ICOS | 细胞表面 [58] | Q9Y6W8 | 29851 | 2 | R & D, ATCC | ||
IL-1R | 细胞表面 [58] | P14778 | 3554 | 2 | R & D (2) | ||
GATA-3 | 转录因子 [61] | P23771 | 2625 | 2 | SCBT (2) | ||
CCR8 | 趋化因子, 趋化因子受体 [59, 62] | P51685 | 1237 | 2 | Alexis (1), Berlex Biosciences (1) | ||
IL-9 | 分泌 | P15248 | 3578 | 0 | |||
Jurkat cells | |||||||
CD45 | 细胞表面 [63] | P08575 | 5788 | 115 | BD (58), Beckman Coulter/Immunotech (24), eBioscience (7) | ||
IL-2 | 分泌 | P60568 | 3558 | 15 | BD (9), R & D (3), Thermo Fisher/Endogen (1) | ||
CD3/CD3E | 细胞表面 [63] | P07766 | 916 | 13 | BD (9), Life Tech (1), Dako (1) | ||
Mast cells | |||||||
CD25 | 细胞表面 [64] | P01589 | 3559 | 41 | BD (22), SCBT (4), Life Tech/Biosource (3) | ||
CD117/c-Kit | 细胞表面 [64] | P10721 | 3815 | 33 | Dako (11), BD (9), SCBT (6) | ||
CD23 | 细胞表面 [64] | P06734 | 2208 | 10 | BD (6), Beckman Coulter (2), Leico/Novocastra (1) | ||
High affinity IgE receptor | 细胞表面 [64] | P12319 | 2205 | 3 | eBioscience (1), EMD Millipore/Upstate (1), Sigma (1) | ||
CD203c | 细胞表面 [64] | O14638 | 5169 | 0 | |||
Retinal ganglion cells | |||||||
PKC alpha | [65] | P17252 | 5578 | 9 | EMD Millipore (3), SCBT (1), CST (1) | ||
NGF | [66] | P01138 | 4803 | 1 | Promega (1) | ||
Brn3b | [65] | Q12837 | 5458 | 1 | SCBT (1) | ||
NSCL2 | [66] | P21675 | 6872 | 0 | |||
Hu-1 | [65] | P09067 | 3215 | 0 | |||
Pyramidal cells | |||||||
MAP2 | 锥体细胞树突 [67-69] | P11137 | 4133 | 36 | Sigma (15), EMD Millipore (11), BD (3) | ||
SMI-32/CD3epsilon | [70-72] | P07766 | 916 | 13 | BD (9), Life Tech (1), Dako (1) | ||
PSD-95 | 锥体神经元树突 [73] | P78352 | 1742 | 10 | Thermo Fisher (6), EMD Millipore (2), SCBT (1) | ||
CaMK2 alpha | [74] | Q9UQM7 | 815 | 4 | SCBT (1), EMD Millipore/Chemicon (1), Enzo (1) | ||
mGluR1 | Q13255 | 2911 | 1 | EMD Millipore | |||
mGluR5 | CA1锥体神经元中表达的主要突触后mGluR [75, 76] | P41594 | 2915 | 1 | EMD Millipore | ||
Tbr1 | 早期锥体神经元标记 [77] | Q16650 | 10716 | 1 | EMD Millipore | ||
RPTPgamma | 神经系统中的锥体细胞和感应神经元 [78] | P23470 | 5793 | 1 | Miltenyl | ||
MATH-2 | marker of hippocampal pyramidal cells [79] | Q96NK8 | 63974 | 0 | |||
SCIP | 海马体锥体细胞标记 [79, 80] | Q03052 | 5453 | 0 | |||
Emx1 | 椎体神经元 [81] | Q04741 | 2016 | 0 | |||
Zfp312 | 层V和VI皮层下投影锥体神经元 [82] | Q8TBJ5 | 55079 | 0 | |||
神经颗粒素/RC3 | [83, 84] | Q92686 | 4900 | 0 | |||
Germ cells | |||||||
EGFR | 搞完生殖细胞肿瘤内的syncytiotrophoblastic细胞 [85] | P00533 | 1956 | 60 | Life Tech/Biosource (12), EMD Millipore (9), SCBT (8) | ||
OCT3/4 | 生殖细胞肿瘤,比如性腺母细胞瘤和原位癌,侵袭性胚胎性癌以及精元瘤 [86] | Q01860 | 5460 | 3 | SCBT, EMD Millipore, Abcam | ||
AP-2gamma | 生殖母细胞和精元生殖细胞瘤 [87, 88] | Q92754 | 7022 | 1 | SCBT | ||
DAZ-like 1/DAZL1 | 雄性和雌性生殖腺 [89] | Q92904 | 1618 | 0 | |||
MAGE-A4 | testicular tumors [90] | P43358 | 4103 | 0 | |||
VASA | 正常和恶性的人生殖细胞 [91] | Q9NQI0 | 54514 | 0 | |||
ZAR1 | [92] | Q86SH2 | 326340 | 0 | |||
RBM | 正常的雄性生殖细胞 [93] | P0DJD3 | 5940 | 0 | |||
Tesmin | 雄性生殖细胞分化 [94] | Q9Y4I5 | 9633 | 0 | |||
TEX101 | 雄性和雌性生殖细胞 [95] | Q9BY14 | 83639 | 0 | |||
GCNA1 | only for mouse [92, 96] | ||||||
GP90-MC301 | 产前和产后检测的生殖细胞 [97] | ||||||
M2A | CIS生殖细胞 [98] | ||||||
施旺细胞 | |||||||
胶质纤维酸性蛋白/GFAP | 非髓鞘施旺细胞 | P14136 | 2670 | 79 | Dako (35), Sigma (19), EMD Millipore (11) | ||
S100A1 | P23297 | 6271 | 19 | Dako (12), Sigma (2), EMD Millipore (1) | |||
髓鞘碱性蛋白/MBP | 髓鞘施旺细胞 | P02686 | 4155 | 17 | EMD Millipore (7), Dako (3), CST (2) | ||
髓鞘蛋白零 | 髓鞘施旺细胞 | P25189 | 4359 | 0 | |||
Purkinje cells | |||||||
GABA-T/γ-氨基丁酸转氨酶 | 浦肯野细胞分化标记 [99, 100] | P80404 | 18 | 4 | Sigma | ||
钙结合蛋白 | 小脑浦肯野细胞 [101] | P05937 | 793 | 17 | Sigma (9), Swant (7), EMD (1) | ||
NMDA-NR1/NMDA-R1 受体亚型 | 成人小脑浦肯野细胞 [102] | Q05586 | 2902 | 6 | EMD (4), BD (2) | ||
谷氨酸脱羧酶GAD67/67-kDa同型 | 浦肯野细胞分化标记 [100] | Q99259 | 2571 | 5 | EMD (2), Enzo, Sigma | ||
PMCA/质膜钙泵 | 更远端树突浦肯野细胞 [103] | P20020 | 490 | 5 | Thermo Fisher (3), Enzo (1) | ||
HDAC6 | 大多数神经元都能表达但在小脑浦肯野细胞中丰富 [104] | Q9UBN7 | 10013 | 2 | SCBT | ||
cGMP-依赖型蛋白激酶 | [105] | Q13976 | 5592 | 2 | SCBT, Enzo | ||
PMCA2/质膜Ca(2+)-运输ATP酶-2 | [106, 107] | Q01814 | 491 | 2 | Thermo Fisher | ||
丛生蛋白 | 人类大脑缺血浦肯野细胞 [108] | P10909 | 1191 | 1 | SCBT | ||
PDE5 | [109, 110] | O76074 | 8654 | 1 | Abcam | ||
肌醇1,4,5 - 三磷酸受体/IP3R | [111-113] | Q14643 | 3708 | 1 | EMD | ||
Zebrin II/醛缩酶 | [114-120] | P09972 | 230 | 0 | |||
PDE1B | [109, 110] | Q01064 | 5153 | 0 | |||
SERCA | [121] | Q93084 | 489 | 0 | |||
钙调素依赖性磷酸二酯酶/PDE1A | 在小脑浦肯野细胞表达水平高 [122] | P14100 | 281969 | 0 | |||
Car8 | 在小脑浦肯野细胞表达水平高 [123] | P35219 | 767 | 0 | |||
HFB-16/KIAA0864 Protein | 人类发育小脑中的浦肯野细胞 [124] | Q6WCQ1 | 23164 | 0 | |||
OMP/嗅蛋白 | 后叶浦肯野细胞 [125] | P47874 | 4975 | 0 | |||
PCA-1/PCA-2 | 浦肯野细胞细胞质 [126-128] | P22413 | 5167 | 0 | |||
PDE9A | 啮齿类动物的小脑浦肯野细胞 [129] | O76083 | 5152 | 0 | |||
PEP-19/PEP19 | 小脑浦肯野细胞 [130] | P48539 | 5121 | 0 | |||
小脑肽 | 浦肯野细胞成熟的量化标记 [131, 132] | P23435 | 869 | 0 | |||
鸟苷3':5'-磷酸依赖的蛋白激酶 | [133] | ||||||
MAP-120 | 存在于浦肯野细胞内 [134] | ||||||
PCPP-260/分子量260,000的浦肯野细胞磷酸化蛋白 | 小脑浦肯野细胞 [135, 136] | ||||||
Spot 35 蛋白/S-35 | 小脑浦肯野细胞 [137-142] | ||||||
颗粒细胞 | |||||||
纤连蛋白 | 颗粒细胞细胞分化的标志物 [143] | P02751 | 2335 | 22 | BD (5), Sigma (4), Dako (3) | ||
AMH/抗苗勒管激素 | 性腺肿瘤起源的支持细胞和颗粒细胞的标记 [144] | P03971 | 268 | 5 | SCBT (3), R & D, Beckman Coulter | ||
MCAM/黑色素瘤细胞粘附分子/CD146 | [145] | P43121 | 4162 | 4 | SCBT (1), EMD (1), Enzo (1) | ||
chZPC | 一个特异性的鸡颗粒细胞标记 [146] | P21754 | 778 | 0 | |||
卵泡调节蛋白/FRP | 卵巢颗粒细胞分泌, 颗粒细胞瘤标记 [147] | ||||||
大的黄体细胞 | |||||||
磷酸化 Akt | [148] | P31749 | 207 | 15 | CST (12), SCBT (1), EMD (1) | ||
luteinizing hormone receptor | [149] | P22888 | 3973 | 1 | ATCC | ||
CYP11A1 | 生成类固醇的黄体细胞表达 [150] | P05108 | 1583 | 0 | |||
Sertoli cells | |||||||
波形蛋白 | 成熟的支持细胞 [151, 152] | P08670 | 7431 | 61 | DAKO (24), Sigma (13), SCBT (4) | ||
细胞角蛋白18 | 产前和青春期前的支持细胞 [153-155] | P05783 | 3875 | 19 | Sigma (6), Life Tech (2), Leica/Novocastra (2) | ||
钙网膜蛋白 | 不成熟的支持细胞 [154] | P22676 | 794 | 12 | AWANT (4), Sigma (3), EMD (2) | ||
SCF/干细胞因子 | 由支持细胞生成 [156-160] | P21583 | 4254 | 5 | SCBT (1), R & D (1), ENZO (1) | ||
MIS/苗勒抑制物质 | 胎儿睾丸支持细胞 [161] | P03971 | 268 | 5 | SCBT (3), R & D, Beckman Coulter | ||
Sox9 | 调节睾丸中支持细胞的分化 [162-165] | P48436 | 6662 | 3 | SCBT (2), R & D | ||
抑制素B | [166, 167] | P09529 | 3625 | 2 | AbD Serotec | ||
ABP/雄激素结合蛋白 | 支持细胞有功能的标记 [168-170] | P04278 | 6462 | 1 | Fitzgerald | ||
丛生蛋白 | 大鼠支持细胞 [171, 172] | P10909 | 1191 | 1 | SCBT | ||
GATA-1 | Sertoli cells at specific seminiferous tubule stages [173] | P15976 | 2623 | 1 | SCBT | ||
GATA-4 | 生精线中的胎儿睾丸支持细胞 [174-178] | P43694 | 2626 | 1 | SCBT | ||
Dhh/desert hedgehog | [179-183] | O43323 | 50846 | 0 | |||
5 - 羟色胺受体1A | 正常睾丸中的支持细胞 [184, 185] | P08908 | 3350 | 0 | |||
M2A | 不成熟的支持细胞 [186, 187] | ||||||
周期蛋白-2/CP-2 | 支持细胞分泌 [188-191] |
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- Rodgers K, Marks J, Ellefson D, Yanagihara D, Tonetta S, Vasilev S, et al. Follicle regulatory protein: a novel marker for granulosa cell cancer patients. Gynecol Oncol. 1990;37:381-7 pubmed
- Pautier P, Bidart J, Lallou N, Duvillard P, Michel G, Droz J, et al. [Value of inhibin as a tumor marker in granulosa cell tumors. Apropos of 6 new cases treated at the Gustave-Roussy Institute]. Bull Cancer. 1995;82:557-60 pubmed
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- 来邦网
- 英文来邦
- 基因
- PDE1A
- ABAT
- ATP结合转运蛋白B超家族成员1
- ATP结合转运蛋白G超家族成员2
- ACKR1
- ADAM19
- ALDOC
- 抗苗勒管激素
- ATP2A3
- ATP2B1
- ATP2B2
- Akt
- BAAT
- Brn 3b
- C-kit
- CA8
- CACNA1F
- CAMK2A
- CBLN1
- CCR1
- CCR3
- CCR4
- CCR5
- CCR7
- CCR8
- CD105
- CD11b
- CD11c
- CD123
- CD14
- CD150
- CD16
- CD1B
- CD1C
- CD1a
- CD2
- CD21
- CD23
- CD244
- CD25
- CD27
- CD32
- CD33
- CD34
- CD38
- CD3E
- CD4
- CD43
- CD44
- CD45
- CD55
- CD56
- CD57
- CD59
- CD68
- CD69
- CD83
- CD86
- CD9
- CD90
- CD93
- CD94
- CLEC4C
- CLIP1
- CLU
- CSF2RA
- CXCR1
- CXCR3
- 趋化因子受体4
- CYP11A1
- DAZL
- 直流SIGN
- DHH
- 二肽基肽酶4
- E钙粘蛋白
- 内皮细胞选择素
- 表皮生长因子受体
- EMX1
- ENPP3
- FABP7
- FCER1A
- FEZF2
- FGFR3
- FLT3
- Flt-1
- GAD1
- GATA-1
- GATA-4
- GATA3
- GRM1
- GRM5
- HDAC6
- HLA-A
- HLA-DQA2
- HOXB5
- HTR1A
- ICAM-1
- ICOS
- IFN丙
- IFNGR1
- IL-10
- IL-12
- IL-13
- 白细胞介素15
- IL-18
- IL-4
- IL-6
- IL18R1
- IL1R1
- IL3
- 白细胞介素-9
- INHBB
- IRF7
- IRF8
- ITGA1
- ITGA4
- ITGA6
- ITPR1
- KIR3DL1
- KITLG
- KLRB1
- KLRF1
- KRT10
- KRT15
- KRT16
- KRT2
- KRT3
- KRT5
- KRT6A
- KRT8
- LAMP-1
- LAMP3
- LFA-1
- LHCGR
- LIN28A
- LTA
- LY75
- MAGEA4
- 微管相关蛋白2
- 髓磷脂碱蛋白
- MCAM
- MPL
- MPRIP
- MPZ
- MRPS22
- MTL5
- 粘蛋白1
- NCR1
- NEUROD6
- 神经生长因子
- NKG2A
- NR1
- OMP
- OR3A3
- Oct4
- PC 1
- PCP4
- PDE1B
- PDE5A
- PDE9A
- PDGFR乙
- 血小板-内皮细胞粘附分子1
- PKC甲
- POU3F1
- PRKG1
- PSD-95
- PTPRG
- PVRL1
- RBMY1A1
- S100
- SCNN1A
- SCNN1B
- SCNN1D
- SCNN1G
- SFTPA1
- SFTPB
- SFTPC
- Sox9
- T bet
- T大脑1
- TAF1
- TEX101
- TFAP2C
- TLR7
- Toll样受体9
- 肿瘤坏死因子甲
- TNFR1
- Tim 3
- UCHL1
- VASA
- VE钙粘蛋白
- VEGFR-2
- Vegfr-3
- ZAR1
- apelin
- β1整合素
- calbindin
- calretinin
- 胱氨酸-天冬氨酸蛋白酶3
- 细胞角蛋白14
- 细胞角蛋白18
- 细胞角蛋白7
- 细胞角蛋白
- eNOS
- 纤维连接蛋白
- 胶质纤维酸性蛋白
- 整合素αⅤ
- 整合素α2
- 整合素α3
- 整合素α5
- 白细胞介素2
- 白细胞介素5
- 淋巴乙受体
- neurofilament L
- 神经颗粒
- p75NTR
- 前列腺特异抗原
- 性激素结合球蛋白
- 表面活性剂蛋白D
- 存活素
- 血栓调节蛋白
- tie-2
- 转铁蛋白受体
- 弹性蛋白
- 血管假性血友病因子